Abstract | BACKGROUND: Incomplete resorption of fructose results in increased colonic hydrogen production and is a frequent cause of abdominal symptoms. The only treatment available is diet. AIM: METHODS: Patients received 25 g fructose in 100 mL water together with either placebo or XI capsules. Primary endpoint was the reduction in breath hydrogen excretion, as assessed by the area under the breath hydrogen curve over 4 h (AUC). A secondary endpoint was the reduction in abdominal pain, bloating and nausea assessed on a visual analogue scale (VAS, range: 0-10). A P value <0.05 was considered statistically significant. RESULTS: Sixty-five patients in whom fructose malabsorption had been diagnosed by positive breath hydrogen test within the previous year, were included in the study [15 males, 50 females; mean age 43.3 (s.d. = 14.4), range: 21-73 years]. The median AUC was 885 ppm/240 min in the XI group compared to 2071 ppm/240 min in the placebo group (P = 0.00). Median scores for abdominal pain (0.7 vs. 1.3) and nausea (0.2 vs. 0.6), but not for bloating (P = 0.053), were significantly improved after XI (P = 0.009 and P = 0.005) as compared with placebo. CONCLUSIONS:
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Authors | P Komericki, M Akkilic-Materna, T Strimitzer, K Weyermair, H F Hammer, W Aberer |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 36
Issue 10
Pg. 980-7
(Nov 2012)
ISSN: 1365-2036 [Electronic] England |
PMID | 23002720
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2012 Blackwell Publishing Ltd. |
Chemical References |
- Fructose
- Hydrogen
- Aldose-Ketose Isomerases
- xylose isomerase
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Topics |
- Abdominal Pain
(etiology, prevention & control)
- Adult
- Aged
- Aldose-Ketose Isomerases
(administration & dosage)
- Area Under Curve
- Breath Tests
- Double-Blind Method
- Female
- Fructose
(adverse effects)
- Fructose Intolerance
(metabolism, prevention & control)
- Gastritis
(prevention & control)
- Humans
- Hydrogen
(metabolism)
- Intestinal Absorption
(drug effects)
- Male
- Middle Aged
- Nausea
(etiology, prevention & control)
- Pain Measurement
- Young Adult
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