Mycoplasma pneumoniae extract induces an IL-17-associated inflammatory reaction in murine lung: implication for mycoplasmal pneumonia.
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| Abstract |
Mycoplasma pneumoniae (Mp) may cause immune cell reactions as pivotal aspects of this clinically common respiratory pathogen. Our aim is to determine if Mp extract induces a cellular immune response associated with interleukin (IL)-17, leading to lung inflammation and lung injury. BALB/c mice were immunized with Mp extract intraperitoneally followed by its intratracheal administration, to mimic repeated Mp infection found in humans (repeated inoculation, RI group). Those with a single inoculation were compared as single inoculation group (SI group). Analysis of bronchoalveolar lavage fluid (BALF) demonstrated that keratinocyte-derived cytokine, tumor necrosis factor-α, and IL-6 were produced and peaked on days 0.5 or 1, followed by IL-17 on day 2. Levels of these mediators in BALF were higher in RI group than SI group (P < 0.05). Further, significantly more neutrophils were recruited to the lungs of the RI group (P < 0.05). These observations suggest that IL-17 is involved in the prolonged induction of neutrophils in mice treated with Mp extract.
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| Authors | Daisuke Kurai, Kazuhide Nakagaki, Hiroo Wada, Takeshi Saraya, Shigeru Kamiya, Yasunori Fujioka, Koh Nakata, Hajime Takizawa, Hajime Goto |
| Journal | Inflammation (Inflammation) Vol. 36 Issue 2 Pg. 285-93 (Apr 2013) ISSN: 1573-2576 [Electronic] United States |
| PMID | 23001692 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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