Abstract | OBJECTIVES: The aim of this study was to examine whether biomarkers can identify silent cardiac target organ damage (cTOD) in a primary prevention population. BACKGROUND: METHODS: We prospectively recruited 300 asymptomatic individuals already receiving primary prevention therapy. Transthoracic echocardiography, stress echocardiography, and/or myocardial perfusion imaging were performed to identify silent cTOD. RESULTS: One hundred two (34%) patients had evidence of cTOD. Left ventricular hypertrophy was the most prevalent (29.7%) form of cTOD, followed by diastolic dysfunction (21.3%), left atrial enlargement (15.3%), systolic dysfunction (6.3%), and ischemia (6.3%). The area under the curve (AUC) for BNP to identify any form of silent cTOD was 0.78 overall and 0.82 in men. The equivalent figures for hs-cTnT were 0.70 and 0.75 in women. The AUC for BNP and hs-cTnT together was 0.81 and 0.82 in men. However, the discrimination power of other markers was poor, with AUCs of 0.61 for microalbuminuria, 0.49 for uric acid, and 0.58 for eGFR. CONCLUSIONS: In asymptomatic treated primary prevention patients, BNP screening is able to identify existing silent cTOD. The performance of hs-cTnT was not as good as that of BNP. B-type natriuretic peptide plus hs-cTnT together performed best. Prescreening with BNP ± cTnT followed by targeted phenotyping is worth exploring further as a possible way to improve primary prevention.
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Authors | M Adnan Nadir, Sushma Rekhraj, Li Wei, Tiong K Lim, John Davidson, Thomas M MacDonald, Chim C Lang, Ellie Dow, Allan D Struthers |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 60
Issue 11
Pg. 960-8
(Sep 11 2012)
ISSN: 1558-3597 [Electronic] United States |
PMID | 22921971
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Troponin T
- Natriuretic Peptide, Brain
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Topics |
- Aged
- Area Under Curve
- Biomarkers
- Cross-Sectional Studies
- Echocardiography
- Echocardiography, Stress
- Female
- Heart Diseases
(blood, diagnosis, prevention & control)
- Humans
- Male
- Mass Screening
(methods)
- Middle Aged
- Myocardial Perfusion Imaging
- Natriuretic Peptide, Brain
(blood)
- Primary Prevention
- Troponin T
(blood)
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