Specific protein profile in cerebrospinal fluid from HIV-1-positive cART-treated patients affected by neurological disorders.

Abstract

Cytokines/chemokines are involved in the immune response of infections, including HIV-1. We defined the profile of 48 cytokines/chemokines in cerebrospinal fluid from 18 cART patients with chronic HIV-1 infection by Luminex technology. Nine patients were affected with leukoencephalopathies: five with John Cunningham virus (JCV) + progressive multifocal leukoencephalopathy (PML) and four with JCV-not determined leukoencephalopathy (NDLE). In addition, nine HIV-1-positive patients with no neurological signs (NND) and five HIV-1-negative patients affected with acute disseminated encephalomyelitis (ADEM) were enrolled. Ten cytokines (IL-15, IL-3, IL-16, IL-18, CTACK, GRO1, SCF, MCP-1, MIF, SDF) were highly expressed in HIV-1-positive patients while IL-1Ra and IL-17 were present at a lower level. In addition, the levels of IL-17, IL-9, FGF-basic, MIP-1β, and MCP-1 were significantly higher (p < 0.05) in patients with neurological diseases (PML, NDLE, ADEM) with respect to NND. Focusing the attention to the cytokine profile in JCV + PML patients with respect to JCV-NDLE patients, only TNF-β was significantly downregulated (p < 0.05) in JCV + PML patients. This pilot study emphasized the role of immunoregulation in HIV-1-related neurological disorders during cART treatment.

• Authors: Valentina Zanin, Serena Delbue, Annalisa Marcuzzi, Eleonora Tavazzi, Rossella Del Savio, Sergio Crovella, Enrico Marchioni, Pasquale Ferrante, Manola Comar
• Journal: Journal of neurovirology (J Neurovirol) Vol. 18 Issue 5 Pg. 416-22 (Oct 2012) ISSN: 1538-2443 [Electronic] United States
• PMID: 22581428 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-HIV Agents
• Cytokines

Topics

• Adult
• Aged
• Anti-HIV Agents (therapeutic use)
• Cytokines (cerebrospinal fluid, immunology)
• Encephalomyelitis, Acute Disseminated (cerebrospinal fluid, drug therapy, immunology)
• Female
• HIV Infections (cerebrospinal fluid, drug therapy, immunology, virology)
• HIV-1
• Humans
• Leukoencephalopathy, Progressive Multifocal (cerebrospinal fluid, drug therapy, immunology, virology)
• Male
• Middle Aged
• Pilot Projects