Abstract | OBJECTIVE: METHODS: The experiment was conducted from May 2008 to December 2009 in Zhongshan Hospital, Shanghai, China. Forty Sprague Dawley rats were randomized into a normal group (NS group), a lipopolysaccharide model group (LPS group), and dexmedetomidine groups in high dosages (HD), moderate dosages (MD), and low dosages (LD). After the acute lung injury model was duplicated by lipopolysaccharide, the rats in the LD, MD, and HD groups were injected with 0.5 ug/kg, 1.5 ug/kg, and 4.5 ug/kg of dexmedetomidine. The rats in the NS group were injected with normal saline. Immuno-histochemical and reverse transcription polymerase chain reaction techniques were used to assess the damage of lung tissue in each group. RESULTS: CONCLUSION: The inflammatory reactions in lung tissues can be effectively inhibited at doses ranging from 1.5-4.5 ug/kg, resulting in a protective effect on lung tissue.
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Authors | Qi-Qing Shi, Hao Wang, Hao Fang |
Journal | Saudi medical journal
(Saudi Med J)
Vol. 33
Issue 4
Pg. 375-81
(Apr 2012)
ISSN: 1658-3175 [Electronic] Saudi Arabia |
PMID | 22485231
(Publication Type: Journal Article)
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Chemical References |
- Adrenergic alpha-Agonists
- DNA Primers
- Dexmedetomidine
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Topics |
- Acute Lung Injury
(prevention & control)
- Adrenergic alpha-Agonists
(therapeutic use)
- Animals
- Base Sequence
- DNA Primers
- Dexmedetomidine
(therapeutic use)
- Dose-Response Relationship, Drug
- Female
- Male
- Polymerase Chain Reaction
- Rats
- Rats, Sprague-Dawley
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