Abstract | BACKGROUND: AIMS: To test the hypothesis that the UGT1A1*28 allele is associated with lower disease susceptibility to, and disease behavior within, IBD. In addition, a possible altered risk for developing IBD- drug related side-effects was explored. METHODOLOGY: Genomic DNA of 751 patients with IBD (209 patients with ulcerative colitis and 542 patients with Crohn's disease) and 930 healthy controls was genotyped for the UGT1A1*28 promoter polymorphism, and genotype distribution was compared between patients and controls. Genotype phenotype interactions were also investigated. RESULTS: Patients with Crohn's disease significantly less often bear the UGT1A1*28 homozygous genotype compared to the control group, with an odds ratio of 0.64, 95% CI: 0.42-0.98. The ulcerative colitis group showed no significant differences compared to controls. CONCLUSION: The homozygous state of the UGT1A1*28 polymorphism, associated with higher serum bilirubin levels, may be protective for the development of Crohn's disease, suggesting that the anti-oxidant capacity of bilirubin may play a part.
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Authors | Hilbert S de Vries, Rene H M Te Morsche, Kevin Jenniskens, Wilbert H M Peters, Dirk J de Jong |
Journal | Journal of Crohn's & colitis
(J Crohns Colitis)
Vol. 6
Issue 5
Pg. 597-602
(Jun 2012)
ISSN: 1876-4479 [Electronic] England |
PMID | 22398043
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright © 2011 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Biomarkers
- DNA
- UGT1A1 enzyme
- Glucuronosyltransferase
- Bilirubin
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Bilirubin
(blood)
- Biomarkers
(blood)
- Child
- Child, Preschool
- Crohn Disease
(blood, complications, epidemiology)
- DNA
(genetics)
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease
- Genotype
- Glucuronosyltransferase
(blood, genetics)
- Homozygote
- Humans
- Hyperbilirubinemia
(blood, etiology, genetics)
- Male
- Middle Aged
- Netherlands
(epidemiology)
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Prevalence
- Promoter Regions, Genetic
- Risk Factors
- Young Adult
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