Abstract | BACKGROUND: METHODS: Among 67 consecutive patients who received mFOLFOX6 as the adjuvant treatment after resection of metastases from colorectal cancer between September 2002 and March 2009 in our institution, 51 patients who had not received preoperative chemotherapy were reviewed. The mFOLFOX6 treatment comprised oxaliplatin 85 mg/m(2) and l- leucovorin 200 mg/m(2) given intravenously over a 2-h period on day 1, followed by a 5-FU bolus of 400 mg/m(2) and a 46-h infusion of 5-FU 2400 mg/m(2), every 2 weeks for up to 12 cycles. RESULTS: National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0 (NCI-CTC) grade 3-4 toxicities per patient were: peripheral neuropathy 8%, allergic reaction 4%, aspartate transaminase (AST) 4%, febrile neutropenia 4%, nausea 2%, anorexia 2%, fatigue 2%, alanine transaminase (ALT) 2%, bilirubin 2%, neutrophils 49%, leukocytes 6%, and hemoglobin 2%; 71% of the patients completed the scheduled 12 cycles. CONCLUSION:
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Authors | Nozomu Machida, Kouji Yoshizaki, Narikazu Boku, Kentaro Yamazaki, Yusuke Onozawa, Akira Fukutomi, Hirofumi Yasui, Keisei Taku |
Journal | International journal of clinical oncology
(Int J Clin Oncol)
Vol. 18
Issue 2
Pg. 279-84
(Apr 2013)
ISSN: 1437-7772 [Electronic] Japan |
PMID | 22367535
(Publication Type: Journal Article)
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Chemical References |
- Organoplatinum Compounds
- Oxaliplatin
- Leucovorin
- Fluorouracil
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, adverse effects)
- Chemotherapy, Adjuvant
- Colorectal Neoplasms
(drug therapy, pathology, surgery)
- Combined Modality Therapy
- Drug-Related Side Effects and Adverse Reactions
(chemically induced, classification, pathology)
- Female
- Fluorouracil
(administration & dosage, adverse effects)
- Humans
- Japan
- Leucovorin
(administration & dosage, adverse effects)
- Male
- Middle Aged
- Neoplasm Metastasis
(drug therapy)
- Neoplasm Staging
- Organoplatinum Compounds
(administration & dosage, adverse effects)
- Oxaliplatin
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