Modulatory role of glutamic acid on the electrical activities of pain-related neurons in the hippocampal CA3 region.

Abstract

Glutamic acid (Glu) participates in pain modulation of the central nervous system. The CA3 region of the hippocampal formation has been suggested to be involved in nociceptive perception. However, it is unknown whether Glu could modulate the electrical activities of pain-related neurons in the hippocampal CA3 region. The present study aimed to determine the effects of Glu and its receptor antagonist MK-801 in the pain-evoked response of both pain-excited neurons (PENs) and pain-inhibited neurons (PINs) in the hippocampal CA3 region of normal rats. We used a train of electric impulses applied to the sciatic nerve as noxious stimulation. The electrical activities of either PENs or PINs in the hippocampal CA3 region were recorded by a glass microelectrode. The results revealed that intra-CA3 region microinjection of Glu (0.5 μg/1 μl) increased the evoked firing frequency and shortened the firing latency of PEN, while decreased the evoked firing frequency and prolonged the inhibitory duration of PIN in the hippocampal CA3 region of rat evoked by the noxious stimulation. Intra-CA3 region administration of MK-801 (0.25 μg/1 μl) produced the opposite response. These results suggest that Glu and its receptors in hippocampal CA3 region are involved in the modulation of nociceptive information transmission by affecting the electric activities of PENs and PINs.

• Authors: Xu Ma, Tie-feng Shi, Min Zhang, Xiao-Yu Lu, Chun-xiao Yang, Dan Zhu, Dong-xiao Shi, Yue Yang, Chun-lei Wang, Shuang Zhang, Man-ying Xu
• Journal: Neuroscience letters (Neurosci Lett) Vol. 513 Issue 1 Pg. 67-71 (Mar 28 2012) ISSN: 1872-7972 [Electronic] Ireland
• PMID: 22343020 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Excitatory Amino Acid Antagonists
• Receptors, N-Methyl-D-Aspartate
• Glutamic Acid
• Dizocilpine Maleate

Topics

• Animals
• CA3 Region, Hippocampal (cytology, physiopathology)
• Dizocilpine Maleate (pharmacology)
• Electric Stimulation
• Electrophysiological Phenomena (physiology)
• Excitatory Amino Acid Antagonists (pharmacology)
• Extracellular Space (drug effects, physiology)
• Glutamic Acid (pharmacology)
• Microelectrodes
• Neurons (physiology)
• Pain (physiopathology)
• Rats
• Rats, Wistar
• Receptors, N-Methyl-D-Aspartate (antagonists & inhibitors)
• Stereotaxic Techniques