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Dizocilpine Maleate (Dizocilpine)

A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.
Also Known As:
Dizocilpine; MK 801; MK-801; MK801; 5H-Dibenzo(a,d)cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S)-, (Z)-2-butenedioate (1:1)
Networked: 2089 relevant articles (156 outcomes, 277 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Deutsch, Stephen I: 13 articles (05/2014 - 08/2002)
2. Stuchlik, Ales: 10 articles (01/2022 - 08/2004)
3. Mastropaolo, John: 10 articles (03/2010 - 08/2002)
4. Vales, Karel: 9 articles (01/2022 - 08/2004)
5. Manahan-Vaughan, Denise: 9 articles (01/2019 - 11/2007)
6. Rosse, Richard B: 9 articles (03/2010 - 08/2002)
7. Ryu, Jong Hoon: 8 articles (03/2022 - 03/2013)
8. Svoboda, Jan: 7 articles (01/2015 - 01/2008)
9. Souza, Diogo O: 7 articles (02/2010 - 01/2003)
10. Jang, Dae Sik: 6 articles (03/2022 - 12/2013)

Related Diseases

1. Seizures (Absence Seizure)
2. Schizophrenia (Dementia Praecox)
3. Ischemia
4. Brain Ischemia (Cerebral Ischemia)
5. Hypoxia (Hypoxemia)

Related Drugs and Biologics

1. N-Methyl-D-Aspartate Receptors (NMDA Receptors)
2. N-Methylaspartate (NMDA)
3. Dizocilpine Maleate (Dizocilpine)
4. Glutamic Acid (Glutamate)
5. Ketamine
6. Scopolamine (Hyoscine)
7. Glycine (Aminoacetic Acid)
8. Excitatory Amino Acid Antagonists
9. Clozapine (Clozaril)
10. Magnesium

Related Therapies and Procedures

1. Ligation
2. Therapeutics
3. Oral Administration
4. Treatment Delay
5. Injections