Dizocilpine Maleate (Dizocilpine)

A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.

Also Known As:

Networked: 1755 relevant articles (139 outcomes, 205 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Deutsch, Stephen I: 13 articles (05/2014 - 08/2002)
2.	Mastropaolo, John: 10 articles (03/2010 - 08/2002)
3.	Rosse, Richard B: 9 articles (03/2010 - 08/2002)
4.	Souza, Diogo O: 6 articles (02/2010 - 01/2003)
5.	Gmiro, V E: 6 articles (05/2007 - 03/2000)
6.	Chen, Zhong: 6 articles (02/2007 - 04/2003)
7.	Manahan-Vaughan, Denise: 5 articles (05/2015 - 11/2007)
8.	Nikitin, V P: 5 articles (08/2014 - 10/2007)
9.	Solntseva, S V: 5 articles (08/2014 - 10/2007)
10.	Burket, Jessica A: 5 articles (05/2014 - 06/2009)

Related Diseases

1.	Seizures (Seizure) 05/01/2015 - "A modification of the treatment regimen, where DZP was followed 10 min later by MK-801, yielded a reduction in both types of seizures and improved overall outcome. " 10/25/1988 - "MK-801 blocked motor seizures induced by stimulation of hippocampal or amygdala kindled foci, but was more effective in reducing seizure severity and AD duration resulting from stimulation of the hippocampal focus. " 08/01/2001 - "MK-801, at dose levels inducing near sedation, was also effective in modulation of TMPP-induced seizures. " 05/01/2015 - "Joint treatment with both DZP and MK-801 displayed synergistic protection against tonic-clonic seizures and 24 h lethality as determined by isobolographic analysis. " 03/01/2011 - "-treatment with MK-801 (MKH) showed tendency to reduced incidence of convulsions, latency to the first seizure onset and the severity of seizure episodes, but statistical significance was not attained comparing to the H group. "
2.	Schizophrenia (Dementia Praecox) 11/01/2014 - "Given that the postnatal MK-801 treatment represents an animal model of schizophrenia, we propose timely environmental interventions might be an effective strategy in the protection against schizophrenia." 12/01/2013 - "These results suggest that EEPV could be useful for treating schizophrenia because EEPV ameliorates prepulse inhibition disruption and attention deficits induced by MK-801." 11/01/2009 - "If the hyperlocomotion elicited by acutely administered MK-801 is a valid model of at least some aspects of schizophrenia, these results indicate that 1MeTIQ will show efficacy in treating this condition. " 12/01/2013 - "In the present study, we investigated the effects of the ethanolic extract of the spikes of Prunella vulgaris var. lilacina (EEPV) on dizocilpine (MK-801)-induced schizophrenia-like phenotype behaviors such as the disruption of prepulse inhibition and attention deficits in mice. " 06/01/2013 - "Two learning tasks provide evidence for disrupted behavioural flexibility in an animal model of schizophrenia-like behaviour induced by acute MK-801: a dose-response study."
3.	Ischemia 08/01/1989 - "The groups receiving dizocilpine before or up to 20 min. after ischemia all showed a significant reduction in the number of dead neurons as assessed by quantitative histopathology in hippocampus, caudate nucleus and cerebral cortex after one week of recovery. " 02/01/1992 - "Changes of neuronal transmission in the hippocampus after transient ischemia in spontaneously hypertensive rats and the protective effects of MK-801." 10/01/2002 - "MK-801 eliminated ischemia-reperfusion evoked alteration of PI-TPs. " 10/01/1996 - "In conclusion, the combination of MK-801 and PBN increases both the efficacy and the time window of protection against ischemia." 11/01/2005 - "This study examined the impact of MK-801 on cerebral blood flow (CBF) and its relationship to gene expression changes during focal ischemia. "
4.	Memory Disorders (Memory Loss) 11/01/2014 - "We found that EE not only has beneficial effects on cognitive performance of normal rats but also prevents spatial learning and memory deficits in Morris water maze induced by MK-801. " 10/01/2008 - "NFPS significantly ameliorated reference memory deficits in a radial maze that occurred following MK801 treatment. " 09/20/2002 - "On the other hand, MK-801 caused significant spatial memory deficits in obese rats in comparison with lean rats. " 03/01/1999 - "MK-801 improves retention in aged rats: implications for altered neural plasticity in age-related memory deficits." 01/01/1999 - "Following recovery of the spatial memory deficits produced by the brain lesion (four weeks after the brain lesion), dizocilpine (0.1 mg/kg) significantly impaired both reference and working memory, without affecting general behavior or food intake in the brain-lesioned rats. "
5.	Brain Ischemia (Cerebral Ischemia) 08/26/1996 - "The present study was designed to evaluate whether the neuroprotective efficacy of MK-801 in focal cerebral ischemia was dependent on strain and/or vendor differences. " 08/26/1996 - "The neuroprotective efficacy of MK-801 in focal cerebral ischemia varies with rat strain and vendor." 05/01/1992 - "Acute improvement in histological outcome by MK-801 following focal cerebral ischemia and reperfusion in the cat independent of blood flow changes." 05/01/1992 - "The present study reports on the acute effects of MK-801 on the histopathological outcome and blood flow changes during focal cerebral ischemia and reperfusion. " 12/01/1989 - "In the circumstance of complete cerebral ischemia as employed in the current study, MK-801 had no beneficial effect upon neurologic or neuropathologic outcome."

Related Drugs and Biologics

1.	N-Methylaspartate (NMDA)
2.	Dizocilpine Maleate (Dizocilpine)
3.	Glutamic Acid (Glutamate)
4.	Ketamine
5.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
6.	Glycine (Aminoacetic Acid)
7.	Phencyclidine (Angel Dust)
8.	Scopolamine (Hyoscine)
9.	Clozapine (Clozaril)
10.	Magnesium

Related Therapies and Procedures

1.	Ligation
2.	Injections
3.	Spinal Injections
4.	Analgesia
5.	Intraperitoneal Injections