Lack of association between essential hypertension and GSTO1 uncommon genetic variants in Italian patients.

Abstract

BACKGROUND AND OBJECTIVE:

Essential hypertension (EH) is a complex phenotype that is affected by multiple genetic and environmental factors. Some authors have explored the role of genetic variability of the glutathione S-transferase (GST) enzymes in EH risk with contrasting results. In particular, our previous study investigated two GSTO common polymorphisms, but we did not find a significant outcome. The aim of this research was to analyze two GSTO1 uncommon variants (E155del and E208K) in 193 EH patients and 210 healthy controls.

RESULTS:

The genetic association analysis did not find significant outcome between GSTO1 uncommon variants and EH: both single-locus and haplotype investigations did not reach the statistical significance levels. Nevertheless, the correspondence analysis seems to highlight a difference between sexes: female EH patients seem to be more related to E155/del155 and E208/K208 genotypes than male patients.

CONCLUSIONS:

Our studies confirm the lack of association between GSTO1 variants and EH risk, also for two uncommon genetic variants with large functional effects. However, our study highlighted some hypotheses (sex-specific marker, antioxidant function, arsenic metabolism, and modulation of inflammation processes) that might help to clarify the potential role of GSTO1 in EH pathophysiology.

• Authors: Renato Polimanti, Sara Piacentini, Natalia Lazzarin, Maria Antonietta Re, Dario Manfellotto, Maria Fuciarelli
• Journal: Genetic testing and molecular biomarkers (Genet Test Mol Biomarkers) Vol. 16 Issue 6 Pg. 615-20 (Jun 2012) ISSN: 1945-0257 [Electronic] United States
• PMID: 22283150 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• GSTO1 protein, human
• Glutathione Transferase

Topics

• Female
• Gene Frequency
• Genotype
• Glutathione Transferase (genetics)
• Haplotypes
• Humans
• Hypertension (genetics)
• Italy
• Male
• Middle Aged
• Polymorphism, Genetic
• Sex Factors
• White People (genetics)