Abstract | BACKGROUND: We previously reported the efficacy of extensive eradication of infectious foci in oral and ENT lesions, combined with tonsillectomy plus methylprednisolone (MP) pulse therapy, for curing pediatric Henoch-Schönlein purpura (HSP) and HSP nephritis. In the present study, we used this therapy in patients with pediatric IgA nephropathy (IgAN) to assess whether similar results could be obtained. PATIENTS AND METHODS: RESULTS: Clinical remission was achieved in all patients with pediatric IgAN (various histologic grades). Remission was achieved by 7.2 ± 5.7 months after initiation of steroid therapy, and disappearance of proteinuria by 3.3 ± 3.0 months. The mean duration of oral steroid administration was 9.5 ± 3.6 months. No relapse has occurred during follow-up of 4.3 ± 2.4 y. CONCLUSIONS: Careful examination and thorough elimination of infectious foci in oral and ENT lesions can optimize the effect of tonsillectomy plus MP pulse therapy, promoting recovery from IgAN.
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Authors | Chiyoko N Inoue, Sachiko Matsutani, Masako Ishidoya, Rikako Homma, Yasushi Chiba, Takako Nagasaka |
Journal | Clinical nephrology
(Clin Nephrol)
Vol. 77
Issue 2
Pg. 137-45
(Feb 2012)
ISSN: 0301-0430 [Print] Germany |
PMID | 22257544
(Publication Type: Journal Article)
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Chemical References |
- Angiotensin Receptor Antagonists
- Methylprednisolone
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Topics |
- Adolescent
- Angiotensin Receptor Antagonists
(therapeutic use)
- Child
- Child, Preschool
- Combined Modality Therapy
- Female
- Glomerulonephritis, IGA
(therapy)
- Humans
- IgA Vasculitis
(therapy)
- Male
- Methylprednisolone
(therapeutic use)
- Periodontitis
(therapy)
- Tonsillectomy
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