Amyloid-β associated volume loss occurs only in the presence of phospho-tau.

Abstract

The relationship between neurodegeneration and the 2 hallmark proteins of Alzheimer's disease, amyloid-β (Aβ) and tau, is still unclear. Here, we examined 286 nondemented participants (107 cognitively normal older adults and 179 memory impaired individuals) who underwent longitudinal magnetic resonance (MR) imaging and lumbar puncture. Using mixed effects models, we investigated the relationship between longitudinal entorhinal cortex atrophy rate, cerebrospinal fluid (CSF) p-tau(181p) and CSF Aβ(1-42) . We found a significant relationship between elevated entorhinal cortex atrophy rate and decreased CSF Aβ(1-42) only with elevated CSF p-tau(181p) . Our findings indicate that Aβ-associated volume loss occurs only in the presence of phospho-tau in humans at risk for dementia.

• Authors: Rahul S Desikan, Linda K McEvoy, Wesley K Thompson, Dominic Holland, J Cooper Roddey, Kaj Blennow, Paul S Aisen, James B Brewer, Bradley T Hyman, Anders M Dale, Alzheimer’s Disease Neuroimaging Initiative
• Journal: Annals of neurology (Ann Neurol) Vol. 70 Issue 4 Pg. 657-61 (Oct 2011) ISSN: 1531-8249 [Electronic] United States
• PMID: 22002658 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 American Neurological Association.

Chemical References

• Amyloid beta-Peptides
• Peptide Fragments
• amyloid beta-protein (1-42)
• tau Proteins

Topics

• Aged
• Aged, 80 and over
• Amnesia (cerebrospinal fluid, pathology)
• Amyloid beta-Peptides (cerebrospinal fluid)
• Atrophy
• Cerebral Cortex (pathology)
• Cognitive Dysfunction (cerebrospinal fluid, pathology)
• Female
• Humans
• Longitudinal Studies
• Male
• Peptide Fragments (cerebrospinal fluid)
• tau Proteins (cerebrospinal fluid)