Antifungal susceptibility of dermatophytes isolated from patients with chronic renal failure.

Abstract

BACKGROUND:

The prevalence of dermatophytosis in the general population is high, particularly in patients with chronic renal failure. Treatment requires the use of topical and/or systemic antifungal drugs. The efficacy of antifungal agents for the treatment of dermatophytosis has yet to be evaluated. Studies evaluating the in vitro activity of antifungal agents are rare, particularly in filamentous fungi.

OBJECTIVE:

To evaluate the susceptibility profile of different species of dermatophytes isolated from patients with chronic renal failure to nine antifungal drugs available on the market for the treatment of dermatophytosis.

METHODS:

Twenty-six isolates of dermatophytes obtained from patients with chronic renal failure were analyzed with respect to their susceptibility to nine antifungal agents (ketoconazole, ciclopirox olamine, fluconazole, griseofulvin, itraconazole, miconazole, piroctone olamine, terbinafine and tioconazole), using the broth microdilution method proposed by the Clinical and Laboratory Standards Institute (CLSI) and adapted for dermatophytes.

RESULTS:

Of the antifungal agents tested, the best results in terms of sensitivity were found with terbinafine and tioconazole, while the antifungal activity of fluconazole was found to be weak, particularly against strains of M. gypseum. Ciclopirox olamine, although less effective than terbinafine, also yielded satisfactory results.

CONCLUSIONS:

In general, the sensitivity profile of the antifungal agents tested in this study was similar to results obtained in previous studies, confirming the need to determine which species is causing the dermatophytosis given that antifungal susceptibility varies from one species to another. Furthermore, the present findings show the importance of conducting in vitro sensitivity tests, since the sensitivity profile may differ among isolates of the same species.

• Authors: Cibele Massotti Magagnin, Cheila Denise Ottonelli Stopiglia, Fabiane Jamono Vieira, Daiane Heidrich, Madeline Machado, Gerson Vetoratto, Flávia Maria Lamb, Maria Lúcia Scroferneker
• Journal: Anais brasileiros de dermatologia (An Bras Dermatol) 2011 Jul-Aug Vol. 86 Issue 4 Pg. 694-701 ISSN: 1806-4841 [Electronic] Spain
• PMID: 21987135 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents

Topics

• Antifungal Agents (pharmacology)
• Humans
• Kidney Failure, Chronic (microbiology)
• Microbial Sensitivity Tests
• Microsporum (drug effects, isolation & purification)
• Trichophyton (drug effects, isolation & purification)