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Fluconazole (Zonal)

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Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS.

Also Known As:

Zonal; AbZ Brand of Fluconazole; Aliud Brand of Fluconazole; Alpharma Brand of Fluconazole; Apo-Fluconazole; Apotex Brand of Fluconazole; Armstrong Brand of Fluconazole; Béagyne; Chemia Brand of Fluconazole; Diflucan; Effik Brand of Fluconazole; Fluc Hexal; FlucoLich; Flucobeta; Fluconazol AL; Fluconazol AbZ; Fluconazol Stada; Fluconazol von ct; Fluconazol-Isis; Fluconazol-ratiopharm; Flunazul; Fungata; Hexal Brand of Fluconazole; Lavisa; Lesvi Brand of Fluconazole; Lichtenstein Brand of Fluconazole; Loitin; Mack Brand of Fluconazole; Neofomiral; Oxifungol; Pfizer Brand of Fluconazole; Pfleger Brand of Fluconazole; SAT Brand of Fluconazole; Silanes Brand of Fluconazole; Solacap; Stada Brand of Fluconazole; Triflucan; UK-49858; Vita Brand of Fluconazole; betapharm Brand of Fluconazole; ct-Arzneimittel Brand of Fluconazole; ratiopharm Brand of Fluconazole; Apo Fluconazole; Fluconazol Isis; Fluconazol ratiopharm; UK 49858; UK49858; ct Arzneimittel Brand of Fluconazole; 1H-1,2,4-Triazole-1-ethanol, alpha-(2,4-difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-

Networked: 4132 relevant articles (625 outcomes, 605 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Azoles: 413
    - Triazoles: 187
      - Fluconazole: 4132
        fosfluconazole: 12

Experts

1.	Walsh, Thomas J: 18 articles (02/2014 - 06/2003)
2.	Harrison, Thomas S: 16 articles (01/2015 - 05/2004)
3.	Sobel, Jack D: 16 articles (12/2012 - 11/2002)
4.	Manzoni, Paolo: 15 articles (05/2014 - 01/2006)
5.	Cornely, Oliver A: 13 articles (01/2015 - 08/2006)
6.	Gupta, Aditya K: 12 articles (09/2015 - 01/2003)
7.	Perfect, John R: 12 articles (01/2015 - 11/2004)
8.	Benjamin, Daniel K: 11 articles (07/2015 - 08/2006)
9.	Kontoyiannis, Dimitrios P: 11 articles (11/2014 - 04/2002)
10.	Marr, Kieren A: 11 articles (09/2013 - 05/2002)

Related Diseases

1.	Infection 12/01/2014 - "Most patients with C albicans infections can be successfully treated with maintenance antifungal therapy, usually with fluconazole. " 12/01/2014 - "Efficacy of prophylactic fluconazole therapy in decreasing the incidence of Candida infections in extremely low birth weight preterm infants." 04/01/2010 - "Efficacy of fluconazole prophylaxis for prevention of invasive fungal infection in extremely low birth weight infants." 01/01/2007 - "Its emergence spectrum varies from mucosal to systemic infections and the first line treatment is still based on fluconazole, a triazole derivate with a potent antifungal activity against most of C. " 02/01/2004 - "Prophylaxis by fluconazole has dramatically reduced the frequency of early Candida infections. "
2.	Candidiasis (Moniliasis) 04/01/1990 - "In summary, fluconazole was most effective against disseminated candidiasis in persistently granulocytopenic rabbits when used for prevention or early treatment." 04/01/1990 - "Fluconazole was most effective when used for preventive or early treatment of acute and subacute disseminated candidiasis. " 10/01/2011 - "In the treatment of oropharyngeal candidiasis, E1210 and fluconazole each caused a significantly greater reduction in the number of oral CFU than the control treatment (P < 0.05). " 08/01/1991 - "Fluconazole is a safe and effective agent with significant activity against chronic disseminated candidiasis." 11/01/1990 - "The convenience, good tolerance and clinical efficacy of fluconazole make it the therapy of choice for oropharyngeal candidiasis in immunologically compromised patients."
3.	Acquired Immunodeficiency Syndrome (AIDS) 07/01/1994 - "High-dose fluconazole appears safe and effective for cryptococcal disease in AIDS patients." 02/01/1996 - "Improved standardization of fluconazole susceptibility testing has resulted in demonstrable correlations between yeast resistance in vitro and in vivo for this agent in the AIDS setting. " 06/01/1991 - "Safety and efficacy of fluconazole treatment for Candida oesophagitis in AIDS." 09/01/2008 - "This study was designed to investigate the: existence of OPC, species distribution fluconazole susceptibility profile of yeast cells isolated from oral specimens of HIV/AIDS patients from Lagos Nigeria, between Oct. " 10/01/2002 - "This study provides important baseline data as the isolates were collected prior to fluconazole being made freely available to HIV/AIDS patients attending government health clinics."
4.	Cryptococcal Meningitis 03/01/1992 - "Fluconazole is highly effective in suppressing relapses of cryptococcal meningitis. " 01/01/2011 - "Improved strategies for earlier diagnosis and treatment of HIV, implementation of fluconazole pre-emptive treatment for high-risk patients and acquisition of better resources for treatment of cryptococcal meningitis are needed." 07/01/1994 - "Eight patients (6, cryptococcal meningitis; 2, high-titer cryptococcal antigenemia) were treated with 800 mg/day fluconazole to assess the safety and efficacy of high-dose fluconazole as primary therapy. " 03/01/1992 - "Fluconazole, an orally active antifungal agent, has been shown to be clinically beneficial for maintenance therapy of cryptococcal meningitis. " 03/04/1995 - "Although the optimum dose and duration of fluconazole could not be determined, our results suggest that less than daily use was effective in the prevention of cryptococcal meningitis."
5.	Cryptococcosis 08/01/1986 - "Fluconazole was highly effective in suppressing cryptococcosis in mice challenged by the intravenous and intranasal routes, and was comparable with the other two drugs in its protective capacity. " 06/15/2003 - "Fluconazole is useful in the treatment of CNS cryptococcosis, because it attains high concentration in the CNS. " 09/01/2006 - "Fluconazole is effective in the treatment of pulmonary cryptococcosis in these patients." 01/01/1995 - "Treatment with fluconazole was effective in 2 months on the cryptococcosis. " 01/01/1992 - "In primary treatment of cryptococcosis, fluconazole is well tolerated, but is effective in only 50% of patients. "

Related Drugs and Biologics

1.	Itraconazole (Sporanox)
2.	Amphotericin B (Amphotericin)
3.	Ketoconazole (Nizoral)
4.	terbinafine (Lamisil)
5.	Flucytosine (Ancobon)
6.	voriconazole (Vfend)
7.	caspofungin (Cancidas)
8.	posaconazole
9.	Nystatin (Mycostatin)
10.	anidulafungin

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Catheters
3.	Transplants (Transplant)
4.	Transplantation (Transplant Recipients)
5.	Vitrectomy