Abstract | BACKGROUND AND PURPOSE: METHODS: RESULTS: CONCLUSIONS: That postischemic blood-brain barrier permeability and brain edema are increased during hyperlipidemia points toward the importance of the recognition and adequate treatment of this highly prevalent condition. Translational studies should more adequately mimic risk factors prevalent in human stroke.
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Authors | Ayman ElAli, Thorsten R Doeppner, Anil Zechariah, Dirk M Hermann |
Journal | Stroke
(Stroke)
Vol. 42
Issue 11
Pg. 3238-44
(Nov 2011)
ISSN: 1524-4628 [Electronic] United States |
PMID | 21836084
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Calpain
- Capn1 protein, mouse
- CAPN2 protein, human
- Matrix Metalloproteinase 2
- Mmp2 protein, mouse
- Matrix Metalloproteinase 9
- Mmp9 protein, mouse
- RhoA protein, mouse
- rho GTP-Binding Proteins
- rhoA GTP-Binding Protein
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Topics |
- Animals
- Blood-Brain Barrier
(enzymology)
- Brain Edema
(enzymology, etiology, pathology)
- Brain Ischemia
(enzymology, pathology)
- Calpain
(metabolism)
- Capillary Permeability
(physiology)
- Enzyme Activation
(physiology)
- Hyperlipidemias
(complications, enzymology, pathology)
- Lipid Peroxidation
(physiology)
- Male
- Matrix Metalloproteinase 2
(metabolism)
- Matrix Metalloproteinase 9
(metabolism)
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- rho GTP-Binding Proteins
(metabolism)
- rhoA GTP-Binding Protein
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