Carbon dioxide-enriched water inhalation in patients with allergic rhinitis and its relationship with nasal fluid cytokine/chemokine release.

Abstract

BACKGROUND AND AIMS:

Allergic rhinitis is characterized by eosinophil infiltration and accumulation in the nasal mucosa mainly due to IL-3, IL-5, and eotaxin activities. We undertook this study to investigate a possible in vivo effect of carbon dioxide-enriched water inhalation in patients with allergic rhinitis.

METHODS:

Twenty five consecutive patients inhaled carbon dioxide-enriched water at Fonti di Rabbi Spa Centre (Trento, Italy). Symptom scores for nasal obstruction, itching and sneezing were obtained before and after treatment. Nasal lavage was collected, and IL-3, IL-5, and eotaxin levels were assessed using the quantitative sandwich enzyme immunoassay technique. Cytometric analysis was performed on samples to measure total cell count, CD45+ cells, and percentages of polymorphonucleates and lymphocytes.

RESULTS:

There were statistically significant differences in chemokine levels and in cell populations between patients and healthy controls before treatment. After carbon dioxide-enriched water inhalation, we observed statistically significant improvements in symptom scores, chemokine levels, and percentages of cell populations.

CONCLUSIONS:

Our results seem to confirm the role of IL-3, IL-5, and eotaxin in the pathophysiology of allergy and the beneficial effect of carbon dioxide-enriched water inhalation in patients affected by allergic rhinitis.

• Authors: Davide Pagani, Emanuela Galliera, Giada Dogliotti, Mario De Bernardi di Valserra, Sara Torretta, Umberto Solimene, Massimiliano M Corsi, Lorenzo Pignataro
• Journal: Archives of medical research (Arch Med Res) Vol. 42 Issue 4 Pg. 329-33 (May 2011) ISSN: 1873-5487 [Electronic] United States
• PMID: 21820613 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 IMSS. Published by Elsevier Inc. All rights reserved.

Chemical References

• CCL11 protein, human
• Chemokine CCL11
• Chemokines
• Cytokines
• Interleukin-3
• Interleukin-5
• Water
• Carbon Dioxide

Topics

• Administration, Inhalation
• Adolescent
• Adult
• Aged
• Carbon Dioxide (administration & dosage, pharmacology, therapeutic use)
• Chemokine CCL11 (immunology)
• Chemokines (immunology)
• Child
• Cytokines (immunology)
• Female
• Humans
• Interleukin-3 (immunology)
• Interleukin-5 (immunology)
• Male
• Middle Aged
• Nasal Lavage Fluid (chemistry)
• Rhinitis, Allergic, Seasonal (immunology, therapy)
• Water (chemistry)