Abstract | BACKGROUND: METHODS: A randomized placebo controlled pilot study in colorectal cancer patients was performed using calcium carbonate as the test agent in a multi-institutional oncology study group. RESULTS: Two hundred twenty volunteers were randomized in the study. The primary goals of compliance, accrual, and toxicity monitoring are presented. Presence of multiple adenomas at study entry and subsequent development of metachronous adenomas were recorded and found to be associated with synchronous adenomas. The secondary endpoint of recurrent adenomas indicated lower rates of new adenoma in the volunteers randomized to the calcium group. CONCLUSION:
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Authors | David Z J Chu, Michael A Hussey, David S Alberts, Frank L Meyskens Jr, Cecilia M Fenoglio-Preiser, Saul E Rivkin, Glenn M Mills, Jeffrey K Giguere, Charles D Blanke, Gary E Goodman |
Journal | Clinical colorectal cancer
(Clin Colorectal Cancer)
Vol. 10
Issue 4
Pg. 310-6
(Dec 2011)
ISSN: 1938-0674 [Electronic] United States |
PMID | 21782524
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Antacids
- Calcium Carbonate
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Topics |
- Adenoma
(prevention & control)
- Adolescent
- Adult
- Aged
- Antacids
(therapeutic use)
- Calcium Carbonate
(therapeutic use)
- Colorectal Neoplasms
(prevention & control)
- Female
- Humans
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(prevention & control)
- Pilot Projects
- Treatment Outcome
- Young Adult
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