Abstract | OBJECTIVES: METHODS: We conducted a case-control study of Japanese individuals (215 with methamphetamine dependence and 318 age- and sex-matched controls) with three tagging SNPs (rs1630250, rs766288 and rs6662926) selected by HapMap database. RESULTS: rs1630250 was associated in males with methamphetamine dependence in the allele analysis (P-value: 0.0253). However, these results did not remain significant after Bonferroni correction to adjust for multiple comparisons (corrected P-value: 0.152). CONCLUSION: Our findings suggest that TSNAX does not play a role in methamphetamine dependence in the Japanese population. A replication study using larger samples needs to be conducted to obtain conclusive results.
|
Authors | Taro Kishi, Tomo Okochi, Tsuyoshi Kitajima, Hiroshi Ujike, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Christoph U Correll, Nakao Iwata |
Journal | Progress in neuro-psychopharmacology & biological psychiatry
(Prog Neuropsychopharmacol Biol Psychiatry)
Vol. 35
Issue 7
Pg. 1618-22
(Aug 15 2011)
ISSN: 1878-4216 [Electronic] England |
PMID | 21683752
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Central Nervous System Stimulants
- DISC1 protein, human
- DNA-Binding Proteins
- Nerve Tissue Proteins
- TSNAX protein, human
- Methamphetamine
|
Topics |
- Alleles
- Amphetamine-Related Disorders
(epidemiology, genetics, metabolism)
- Asian People
(genetics)
- Bipolar Disorder
(genetics)
- Case-Control Studies
- Central Nervous System Stimulants
(adverse effects, metabolism)
- DNA-Binding Proteins
(genetics, metabolism)
- Depressive Disorder, Major
(epidemiology, genetics, metabolism)
- Female
- Genetic Predisposition to Disease
- Genotype
- HapMap Project
- Haplotypes
- Humans
- Male
- Methamphetamine
(adverse effects, metabolism)
- Nerve Tissue Proteins
(genetics, metabolism)
- Polymorphism, Single Nucleotide
- Schizophrenia
(genetics)
|