Impact of body mass index and viral load on liver histology in hepatitis B e antigen-negative chronic hepatitis B.

Abstract

BACKGROUND & AIMS:

The impact of overweight and obesity on chronic hepatitis B (CHB) is unclear. This study was to examine the relationship among body mass index, viral load and liver histology in HBeAg-negative CHB.

METHODS:

The study retrospectively investigated 136 HBeAg-negative chronic hepatitis B patients who had undergone liver biopsies in Taiwan. Factors associated with significant liver histology were analyzed. Definitions of overweight and obesity for the Asian population were body mass index≥23 kg/m(2) and ≥25 kg/m(2), respectively.

RESULTS:

The prevalence of overweight, obesity, and type 2 diabetes mellitus in the 136 patients were 22.8%, 52.2%, and 12.5%, respectively. Multivariate analysis identified obesity, AST>40 U/L, HBV DNA>20,000IU/mL and platelet count<150 × 10(9)/L as independent factors associated with significant liver fibrosis. Similarly, overweight/obesity, ALT>80 U/L, HBV DNA>1,000,000IU/mL, and platelet count<150 × 10(9)/L were independent predictors of significant hepatic necro-inflammation. By stratification, high BMI and high viral load patients had more advanced stage and grade of liver histology.

CONCLUSIONS:

Body mass index and HBV viral loads may have synergistic effect on disease progression in HBeAg-negative CHB. Both controlling body weight and anti-viral therapy are important in the management of CHB.

• Authors: I-Cheng Lee, Yi-Hsiang Huang, Che-Chang Chan, Teh-Ia Huo, Chi-Jen Chu, Chiung-Ru Lai, Pui-Ching Lee, Chien-Wei Su, Jaw-Ching Wu, Han-Chieh Lin, Shou-Dong Lee
• Journal: Clinical nutrition (Edinburgh, Scotland) (Clin Nutr) Vol. 30 Issue 5 Pg. 647-52 (Oct 2011) ISSN: 1532-1983 [Electronic] England
• PMID: 21612848 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Chemical References

• DNA, Viral
• Hepatitis B Surface Antigens

Topics

• Adult
• Body Mass Index
• DNA, Viral (blood)
• Diabetes Mellitus, Type 2
• Disease Progression
• Female
• Hepatic Insufficiency (etiology)
• Hepatitis B Surface Antigens (blood)
• Hepatitis B virus (isolation & purification, metabolism)
• Hepatitis B, Chronic (complications, pathology, physiopathology, virology)
• Humans
• Liver (immunology, pathology)
• Liver Cirrhosis (etiology)
• Male
• Middle Aged
• Necrosis (etiology, immunology)
• Obesity (complications, epidemiology)
• Overweight (complications, epidemiology)
• Prevalence
• Retrospective Studies
• Taiwan
• Thrombocytopenia (etiology)
• Viral Load