Abstract | PURPOSE OF REVIEW: To review the recent literature describing the detection and clinical importance of serum antibodies in patients with various epilepsies and other seizure-related disorders. RECENT FINDINGS: SUMMARY: An increasing number of antibodies have been described in the epilepsies and other seizure-related disorders. Evidence of direct pathogenicity comes from the extracellular domain targeted by all of these antibodies (other than GAD) and the often dramatic clinical and serological response to immunotherapies, when antiepileptic drugs may be ineffective. Definitive proof as to the pathological relevance of these antibodies will be achieved in the generation of an animal model that demonstrates the clinical phenotype of these antibody-mediated disorders.
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Authors | Sarosh R Irani, Christian G Bien, Bethan Lang |
Journal | Current opinion in neurology
(Curr Opin Neurol)
Vol. 24
Issue 2
Pg. 146-53
(Apr 2011)
ISSN: 1473-6551 [Electronic] England |
PMID | 21358545
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Autoantibodies
- CNTNAP2 protein, human
- Contactins
- Intracellular Signaling Peptides and Proteins
- LGI1 protein, human
- Membrane Proteins
- Nerve Tissue Proteins
- Potassium Channels, Voltage-Gated
- Proteins
- Receptors, AMPA
- Receptors, N-Methyl-D-Aspartate
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Topics |
- Animals
- Autoantibodies
(blood, immunology)
- Autoimmune Diseases
(immunology, physiopathology)
- Clinical Trials as Topic
- Contactins
(immunology)
- Encephalitis
(immunology, physiopathology)
- Epilepsy
(immunology, physiopathology)
- Humans
- Intracellular Signaling Peptides and Proteins
- Membrane Proteins
(immunology)
- Nerve Tissue Proteins
(immunology)
- Potassium Channels, Voltage-Gated
(immunology)
- Proteins
(immunology)
- Receptors, AMPA
(immunology)
- Receptors, N-Methyl-D-Aspartate
(immunology)
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