[Brain-derived neurotrophic factor (BDNF) and mood disorder].

Abstract

Brain-derived neurotrophic factor (BDNF) is the most abundant and widely expressed neurotrophin in the brain. BDNF is believed to play an important role in depressive disorder. Chronic stress decreases the synthesis of hippocampal BDNF, which leads to atrophy of the hippocampus in the depressed patients. Blood BDNF levels also decreased in depressed patients and a correlation is observed between severities of depressive state and blood BDNF levels. Selective serotonin reuptake inhibitors and serotonin noradrenalin reuptake inhibitors both recover the decreased blood BDNF levels. These findings indicate that the blood BDNF level is one of the candidate biomarkers for depression.

• Authors: Reiji Yoshimura, Atsuko Ikenouchi-Sugita, Hikaru Hori, Wakako Umene-Nakano, Asuka Katsuki, Kenji Hayashi, Kiyokazu Atake, Nobuhisa Ueda, Jun Nakamura
• Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology (Nihon Shinkei Seishin Yakurigaku Zasshi) Vol. 30 Issue 5-6 Pg. 181-4 (Nov 2010) ISSN: 1340-2544 [Print] Japan
• PMID: 21226313 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Biomarkers
• Brain-Derived Neurotrophic Factor
• Serotonin Uptake Inhibitors

Topics

• Atrophy
• Biomarkers (blood)
• Brain-Derived Neurotrophic Factor (blood, physiology)
• Hippocampus (pathology)
• Humans
• Mood Disorders (diagnosis, drug therapy, etiology, pathology)
• Neurogenesis
• Neuronal Plasticity
• Selective Serotonin Reuptake Inhibitors (therapeutic use)
• Severity of Illness Index
• Synapses (physiology)