Calf thymus extract attenuates severity of experimental encephalomyelitis in Lewis rats.

Abstract	The aim of this study was to evaluate the efficacy of treatment of Lewis rats with calf thymus extract (TFX®) and its six-peptide fraction on the course of experimental allergic encephalomyelitis (EAE). Interferon- ß served as a reference drug. We found that intramuscular administration of the thymus extract fraction significantly reduced clinical, immunological, histological, and ultrastructural alterations inherent in the disease. We suggest that TFX® or TFX®-derived fractions have potential as therapeutics in treatment of neurodegenerative diseases such as multiple sclerosis.
Authors	Michał Zimecki, Jolanta Artym, Maciej Kocięba, Jan Kuryszko, Katarzyna Kaleta-Kuratewicz, Krzysztof Marycz
Journal	Folia neuropathologica (Folia Neuropathol) Vol. 48 Issue 4 Pg. 246-57 ( 2010) ISSN: 1509-572X [Electronic] Poland
PMID	21225507 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	TFX Thymus Extracts
Topics	Animals Cattle Encephalomyelitis, Autoimmune, Experimental (drug therapy, immunology, pathology) Female Immunohistochemistry Inflammation (drug therapy, immunology, pathology) Rats Rats, Inbred Lew Spinal Cord (drug effects, immunology, pathology) Thymus Extracts (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!