The expression of annexin II and its role in the fibrinolytic activity in acute promyelocytic leukemia.

Abstract

Bleeding in acute promyelocytic leukemia (APL) is mainly associated with disseminated intravascular coagulation and hyperfibrinolysis. Annexin II (Ann II) is a co-receptor for plasminogen and tissue plasminogen activator (tPA). This study demonstrates that abnormally high levels of Ann II expression in APL cells increase the production of plasmin. Hyperfibrinolysis could be corrected by all-trans retinoic acid (ATRA) or ATRA plus arsenic trioxide therapy in patients with APL. SiRNA targetting Ann II caused a decrease in tPA-dependent plasmin generation, while Ann II cDNA transfectant stimulated plasmin production. These results suggest that Ann II play an important role in hyperfibrinolysis in APL.

• Authors: Yanhui Liu, Zhaoyue Wang, Miao Jiang, Lan Dai, Wei Zhang, Depei Wu, Changgeng Ruan
• Journal: Leukemia research (Leuk Res) Vol. 35 Issue 7 Pg. 879-84 (Jul 2011) ISSN: 1873-5835 [Electronic] England
• PMID: 21146216 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Annexin A2
• Arsenicals
• Oxides
• RNA, Messenger
• RNA, Small Interfering
• Tretinoin
• Plasminogen
• Tissue Plasminogen Activator
• Fibrinolysin
• Arsenic Trioxide

Topics

• Adolescent
• Adult
• Aged
• Annexin A2 (antagonists & inhibitors, genetics, metabolism)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Arsenic Trioxide
• Arsenicals (administration & dosage)
• Blood Coagulation Tests
• Blotting, Western
• Cell Proliferation (drug effects)
• Female
• Fibrinolysin (metabolism)
• Fibrinolysis (drug effects, physiology)
• Flow Cytometry
• Humans
• Leukemia, Promyelocytic, Acute (drug therapy, metabolism, pathology)
• Male
• Middle Aged
• Oxides (administration & dosage)
• Plasminogen (metabolism)
• RNA, Messenger (genetics)
• RNA, Small Interfering (genetics)
• Reverse Transcriptase Polymerase Chain Reaction
• Tissue Plasminogen Activator (metabolism)
• Tretinoin (administration & dosage)
• Young Adult