Abstract | OBJECTIVE: CASE SUMMARY: A 71-year-old Chinese man presented with factor V inhibitors after a 7-day cephradine course for a urinary tract infection, characterized by abnormal prothrombin time (PT) and activated partial thromboplastin time (aPTT), gross hematuria, upper gastrointestinal bleeding, and left groin hematoma. Systemic corticosteroid administration restored his factor V activity levels, PT, and aPTT to within normal limits, and hemorrhagic symptoms resolved. Three weeks after successful treatment of bleeding diathesis, he received another 8-day cephradine course for cellulitis. After another 4 weeks, he suffered from recurrent factor V inhibitors presented with abnormal PT, aPTT, and upper gastrointestinal bleeding. The patient eventually died due to hemorrhagic shock despite a second course of corticosteroids. DISCUSSION: CONCLUSIONS: Because cephalosporins are commonly used for their wide therapeutic index and few adverse effects, iatrogenic complications associated with these drugs may be neglected or underdiagnosed. On the basis of our patient's report, careful review of medical records to avoid reexposure to the offending drug cannot be overemphasized.
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Authors | Men-Tai Wu, Sung-Nan Pei |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 44
Issue 10
Pg. 1673-6
(Oct 2010)
ISSN: 1542-6270 [Electronic] United States |
PMID | 20807866
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Autoantibodies
- Factor V
- Cephradine
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Topics |
- Aged
- Anti-Bacterial Agents
(adverse effects, therapeutic use)
- Autoantibodies
(blood)
- Cephradine
(adverse effects, therapeutic use)
- Factor V
(antagonists & inhibitors, immunology)
- Factor V Deficiency
(chemically induced, immunology)
- Fatal Outcome
- Hemorrhage
(chemically induced, immunology)
- Humans
- Male
- Urinary Tract Infections
(drug therapy)
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