Cephalosporins (Cephalosporin Antibiotics)

A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.

Also Known As:

Networked: 2160 relevant articles (156 outcomes, 168 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Paterson, David L: 9 articles (02/2015 - 12/2002)
2.	Romano, Antonino: 8 articles (09/2015 - 01/2002)
3.	Kang, Cheol-In: 8 articles (02/2014 - 09/2004)
4.	Blanca, Miguel: 7 articles (01/2015 - 07/2002)
5.	Mayorga, Cristobalina: 6 articles (01/2015 - 07/2002)
6.	Song, Jae-Hoon: 6 articles (02/2014 - 05/2009)
7.	Chung, Doo Ryeon: 6 articles (02/2014 - 05/2009)
8.	Peck, Kyong Ran: 6 articles (02/2014 - 05/2009)
9.	Centers for Disease Control and Prevention (CDC): 6 articles (08/2012 - 11/2002)
10.	Chiu, Cheng-Hsun: 5 articles (05/2014 - 04/2004)

Related Diseases

1.	Infection 09/01/2010 - "Restriction of all class of cephalosporins significantly decreased the incidence of ESBL gram negative infections." 02/01/1986 - "The new third generation cephalosporins have a significantly greater spectrum of action against gram-negative bacteria likely to be encountered in surgical infections. " 03/01/2012 - "Third-generation cephalosporins may be effective in empirically treating these patients, regardless of the acquisition site of the infection." 07/08/2011 - "Although cephalosporins remain an effective treatment for gonococcal infections, health-care providers should be vigilant for treatment failure and are requested to report its occurrence to state and local health departments. " 06/01/1984 - "As a class, the third generation cephalosporins are less active against gram-positive organisms, but in spite of this they have been clinically effective against infections due to S. "
2.	Meningitis 03/01/2003 - "When Salmonella meningitis is suspected, third-generation cephalosporins, with or without a fluoroquinolone, may be the best option for treatment." 01/01/1995 - "Although the extended spectrum cephalosporins will be effective for most cases of PRP meningitis, it is clear that such therapy is not foolproof. " 05/01/1985 - "Available data confirm that one of the newer "third generation" cephalosporins can be used effectively and safely as a single drug for therapy of meningitis caused by the usual spectrum of bacteria, if the achievable cerebrospinal fluid drug levels exceed the minimal inhibitory concentration of the infecting bacteria by at least 10-fold. " 12/16/1987 - "The prognosis of enterobacterial meningitis has improved with third generation cephalosporins. " 03/01/1993 - "The definition of cephalosporin resistance for pneumococci requires modification and further studies of the antibiotic management of meningitis caused by such strains are needed because resistance to cephalosporins is increasing and the extended spectrum cephalosporins may be ineffective as sole therapy."
3.	Pneumonia (Pneumonitis) 04/02/2001 - "To assess the efficacy of an antibiotic protocol to avoid empirical use of third-generation cephalosporins in community-acquired pneumonia (CAP). " 03/01/2015 - "Guidelines for inpatients with community-acquired pneumonia (CAP) propose to use respiratory fluoroquinolone (RFQ) and/or third-generation cephalosporins (Ceph-3). " 07/01/2014 - "Antibiotic stewardship programs should be implemented to restrict the third-generation cephalosporins use for pneumonia in the emergency department." 07/01/2014 - "Our objectives were to assess the recent trend of third-generation cephalosporins use for pneumonia in the emergency department, and the proportion of avoidable prescriptions. " 07/01/2014 - "Third-generation cephalosporins are used to treat inpatients with community-acquired pneumonia. "
4.	Respiratory Tract Infections (Respiratory Tract Infection) 06/01/2004 - "The aim of the present study was to evaluate two third generation oral cephalosporins for their empirical use in community acquired lower respiratory tract infections in pediatric patients. " 07/01/2012 - "From February 2010 to July 2011, 183 of 416 presumptive Klebsiella pneumoniae isolates with reduced susceptibility to third-generation cephalosporins from patients with lower respiratory tract infection were collected from seven tertiary hospitals in China. " 01/01/2010 - "Community-acquired upper respiratory tract infections and the role of third-generation oral cephalosporins." 09/01/2004 - "Data on the in vitro activities of orally administered cephalosporins, particularly third-generation cephalosporins, against recent pathogens responsible for community-respiratory tract infection are lacking. " 11/01/2002 - "The cephalosporins: targeting respiratory infections."
5.	Peritonitis 12/01/1992 - "This syndrome can be successfully treated with antimicrobial drugs, although the third-generation cephalosporins commonly used in the therapy of spontaneous bacterial peritonitis are not recommended. " 02/01/2012 - "First-line treatment with cephalosporins in spontaneous bacterial peritonitis provides poor antibiotic coverage." 03/01/2004 - "Gold-standard treatment of spontaneous bacterial peritonitis currently involves 3rd generation cephalosporins. " 01/01/2014 - "This case illustrates the potential severe neurologic effects of cephalosporins, which are recommended by international guidelines as first-line antimicrobial therapy for spontaneous bacterial peritonitis. " 05/01/2012 - "Third-generation cephalosporins (TGC) constitute the empirical first-line therapy for spontaneous bacterial peritonitis (SBP). "

Related Drugs and Biologics

1.	Penicillins (Penicillin)
2.	Anti-Bacterial Agents (Antibiotics)
3.	Fluoroquinolones
4.	Aminoglycosides
5.	Ceftriaxone (Ceftriaxon)
6.	Carbapenems (Carbapenem Antibiotics)
7.	Cefotaxime (Kendrick)
8.	beta-Lactamases (beta-Lactamase)
9.	Quinolones
10.	Ampicillin (Omnipen)

Related Therapies and Procedures

1.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
2.	Antibiotic Prophylaxis
3.	Length of Stay
4.	Cesarean Section (Caesarean Section)
5.	Transplantation (Transplant Recipients)