A high-fat diet inhibits the progression of diabetes mellitus in type 2 diabetic rats.

Abstract

It is well known that rats and mice, when fed a high-fat diet, develop obesity associated with abnormal glycolipid metabolism. In this study, we investigated the effects of a high-fat diet on a diabetic rat model, Spontaneously Diabetic Torii (SDT), which develops diabetes due to decreased insulin production and secretion with age. We hypothesized that a high-fat diet would accelerate the induction of diabetes in this model. The SDT rats were divided into 2 groups, which were fed a high-fat diet or standard diet for 16 weeks. The group fed a high-fat diet developed obesity, hyperinsulinemia, and hyperlipidemia until 16 weeks of age. Before 16 weeks of age, hyperglycemia accompanied by hypoinsulinemia developed in the group on a standard diet, but serum glucose levels were comparable in both groups. After 16 weeks of age, the group on a standard diet showed an increase in serum glucose levels and a decrease in serum insulin levels. Unexpectedly, in the group on the high-fat diet, we observed a suppressed of the progression of hyperglycemia/hypoinsulinemia. Histopathological observation revealed more pancreatic beta cells in the group on the high-fat diet. This study suggests that feeding SDT rats a high-fat diet induces obesity, hyperinsulinemia, and hyperlipidemia, but not hyperglycemia, until 16 weeks of age. Thereafter, age-dependent progress of hyperglycemia and hypoinsulinemia was delayed by a high-fat diet. The hyperfunction of pancreatic beta cells induced by a high-fat diet before the onset of hyperglycemia appears to suppress development of hyperglycemia/hypoinsulinemia.

• Authors: Yukihito Ishii, Takeshi Ohta, Tomohiko Sasase, Hisayo Morinaga, Takahiro Hata, Katsuhiro Miyajima, Yoshiaki Katusda, Taku Masuyama, Masami Shinohara, Makoto Kakutani, Mutsuyoshi Matsushita
• Journal: Nutrition research (New York, N.Y.) (Nutr Res) Vol. 30 Issue 7 Pg. 483-91 (Jul 2010) ISSN: 1879-0739 [Electronic] United States
• PMID: 20797481 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2010 Elsevier Inc. All rights reserved.

Chemical References

• Blood Glucose
• Dietary Fats
• Insulin
• Glucagon-Like Peptide 1

Topics

• Adipose Tissue (pathology)
• Animals
• Blood Glucose (analysis)
• Body Weight
• Diabetes Mellitus, Type 2 (pathology, physiopathology, prevention & control)
• Diet
• Dietary Fats (administration & dosage)
• Energy Intake
• Glucagon-Like Peptide 1 (blood)
• Glucose Tolerance Test
• Insulin (blood)
• Male
• Pancreas (pathology)
• Proteinuria (urine)
• Rats