Abstract |
Tocopherols, which exist in alpha, beta, gamma, and delta forms, are antioxidative nutrients also known as vitamin E. Although alpha-tocopherol (alpha-T) is the major form of vitamin E found in the blood and tissues, gamma- and delta-T have been suggested to have stronger anti-inflammatory activities. In the present study, using a tocopherol mixture that is rich in gamma-T (gamma-TmT, which contains 57%gamma-T), we demonstrated the inhibition of inflammation as well as of cancer formation and growth in the lung and colon in animal models. When given in the diet at 0.3%, gamma-TmT inhibited chemically induced lung tumorigenesis in the A/J mice as well as the growth of human lung cancer cell H1299 xenograft tumors. gamma-TmT also decreased the levels of 8-hydroxydeoxyguanosine, gamma-H2AX, and nitrotyrosine in tumors. More evident anti-inflammatory and cancer preventive activities of dietary gamma-TmT were demonstrated in mice treated with azoxymethane and dextran sulfate sodium. These results demonstrate the antioxidative, anti-inflammatory, and anticarcinogenic activities of tocopherols.
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Authors | Chung S Yang, Gang Lu, Jihyeung Ju, Guang Xun Li |
Journal | Annals of the New York Academy of Sciences
(Ann N Y Acad Sci)
Vol. 1203
Pg. 29-34
(Aug 2010)
ISSN: 1749-6632 [Electronic] United States |
PMID | 20716280
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Chemical References |
- Antineoplastic Agents
- Antioxidants
- Inflammation Mediators
- Tocopherols
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Topics |
- Animals
- Antineoplastic Agents
(pharmacology, therapeutic use)
- Antioxidants
(pharmacology, therapeutic use)
- Cell Transformation, Neoplastic
(metabolism, pathology)
- Colonic Neoplasms
(metabolism, pathology, prevention & control)
- Humans
- Inflammation Mediators
(antagonists & inhibitors, physiology, therapeutic use)
- Lung Neoplasms
(metabolism, pathology, prevention & control)
- Tocopherols
(pharmacology, therapeutic use)
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