[Effects of deer tendons collagen on osteoporosis rats induced by retinoic acid].

Abstract

OBJECTIVE:

To study the effects of deer tendons collagen on osteoporosis rats induced by retinoic acid.

METHODS:

Male Wistar rats were randomly divided into normal control group, model control group, deer tendons collagen high, medium and low-dose groups, osteoporosis rats of retinoic acid-induced were set up. Changes of body weight, bone weight, bone mineral density, bone histomorphometry, plasma phosphorus, calcium, alkaline phosphatase (ALP), bone mechanics were measured before and after treatment of deer tendons collagen.

RESULTS:

Compared with model control group,after treated by deer tendons collagen, body weight, bone mineral density, bone weight was increased in varying degrees, bone histomorphometry parameters were significantly different, the ALP in plasma was significantly reduced, contents of Ca, P were increased, all indicators of bone mechanics were significantly higher.

CONCLUSION:

Deer tendons collagen can prevent and treat retinoic acid-induced osteoporosis of rats.

• Authors: He Zhang, Yu Zhao, Yin-Qing Li, Xiao-Di Sun, Xue-Yuan Bai, Da-Qing Zhao
• Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (Zhong Yao Cai) Vol. 33 Issue 3 Pg. 411-4 (Mar 2010) ISSN: 1001-4454 [Print] China
• PMID: 20681309 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Materia Medica
• Tretinoin
• Collagen
• Alkaline Phosphatase
• Calcium

Topics

• Alkaline Phosphatase (blood, metabolism)
• Animals
• Biomechanical Phenomena
• Bone Density (drug effects)
• Calcium (blood)
• Collagen (isolation & purification, pharmacology, therapeutic use)
• Deer
• Disease Models, Animal
• Femur (drug effects, metabolism)
• Male
• Materia Medica (pharmacology, therapeutic use)
• Osteoporosis (chemically induced, drug therapy, prevention & control)
• Random Allocation
• Rats
• Rats, Wistar
• Tendons
• Tretinoin