Increase in plasma glucagon, a factor in hyperglycemia, is related to neurological outcome in postcardiac-arrest patients.
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| Abstract | AIM OF THE STUDY: In postcardiac-arrest (PCA) patients, hyperglycemia is a factor reflecting an unfavorable outcome, and might be caused by the inflammation and stress of "sepsis-like" syndrome. In this study, plasma glucagon, a representative glycogenolytic and gluconeogenic hormone, was measured and assessed the correlation for neurological outcome in PCA patients. METHODS: This study was a retrospective, single-medical-center analysis, conducted in the intensive care unit of a university hospital. Twenty-four sequential PCA patients were included. Plasma samples were collected from the patients on days 1, 2, and 3 after the return of spontaneous circulation (ROSC). Glucagon was compared in patients with favorable and unfavorable neurological outcomes. RESULTS: At all time points, plasma glucagon was significantly higher in patients with an unfavorable outcome (P<0.05). Glucagon on day 1 had remarkable sensitivity (88.2%) and specificity (85.8%) as an indicator of outcome, and correlated with the collapse-ROSC interval, the start of cardiopulmonary resuscitation (CPR)-ROSC interval, and the epinephrine dose during CPR. CONCLUSIONS: Plasma glucagon reflects unfavorable outcomes in PCA patients, and might be related to ischemic and reperfusion stress.
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| Authors | Chiyomi Oshima, Tadashi Kaneko, Ryosuke Tsuruta, Yasutaka Oda, Takashi Miyauchi, Motoki Fujita, Yoshikatsu Kawamura, Shunji Kasaoka, Tsuyoshi Maekawa |
| Journal | Resuscitation (Resuscitation) Vol. 81 Issue 2 Pg. 187-92 (Feb 2010) ISSN: 1873-1570 [Electronic] Ireland |
| PMID | 20015588 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | Copyright 2009 Elsevier Ireland Ltd. All rights reserved. |
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