Abstract | BACKGROUND: METHODS: Male Sprague-Dawley rats were anesthetized, and the right fourth and fifth ribs were surgically exposed. The pleura was opened, and the ribs were retracted. Intercostal RTX 0.8 or 8 microg was injected in animals that developed allodynia after surgery; a control group underwent rib retraction and received vehicle only. An additional group of uninjured animals received RTX. Rats were tested for mechanical allodynia at a predetermined area around the incision site for 3 wk. RESULTS:
Allodynia developed in 42% of the animals that underwent thoracotomy. A transient hyperalgesic response was noted in the uninjured group that underwent drug injections. Intercostal RTX did not modify the course of allodynia in injured rats. DISCUSSION: The current results suggest that intercostal RTX causes a transient hyperalgesic response in uninjured animals and is ineffective in reducing the mechanical allodynia after thoracotomy.
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Authors | Jin-Woo Shin, Carlo Pancaro, Chi Fei Wang, Peter Gerner |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 110
Issue 1
Pg. 228-32
(Jan 01 2010)
ISSN: 1526-7598 [Electronic] United States |
PMID | 19933535
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Diterpenes
- resiniferatoxin
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Topics |
- Animals
- Diterpenes
(administration & dosage, therapeutic use)
- Hyperalgesia
(chemically induced)
- Injections
- Intercostal Nerves
- Male
- Nerve Block
- Pain Measurement
- Pain Threshold
(drug effects)
- Pain, Postoperative
(drug therapy)
- Rats
- Rats, Sprague-Dawley
- Thoracotomy
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