Neostigmine (Neostigmine Bromide)

A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.

Also Known As:

Networked: 829 relevant articles (60 outcomes, 88 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Korsten, Mark A: 4 articles (10/2015 - 01/2004)
2.	Spungen, Ann M: 4 articles (10/2015 - 01/2004)
3.	Bauman, William A: 4 articles (10/2015 - 01/2004)
4.	Nezhinskaia, G I: 4 articles (05/2010 - 07/2005)
5.	Sapronov, N S: 4 articles (05/2010 - 07/2005)
6.	Roelants, Fabienne: 4 articles (06/2006 - 04/2003)
7.	Bharucha, A E: 3 articles (12/2015 - 11/2001)
8.	Rosman, Alan S: 3 articles (10/2015 - 07/2005)
9.	Radulovic, Miroslav: 3 articles (10/2015 - 01/2004)
10.	Sessler, Daniel I: 3 articles (02/2015 - 07/2002)

Related Diseases

1.	Myasthenia Gravis 01/01/2014 - "Symptoms of myasthenia gravis (measured as improvement in at least one muscle function) improved in nine of the 10 participants after the two-week neostigmine treatment phase. " 03/01/1992 - "The efficacy of intranasally administered neostigmine was tested in 22 patients with generalized myasthenia gravis (MG). " 05/01/1978 - "Since the myopathic changes observed in this study were produced by neostigmine, a drug which is commonly employed in the routine treatment of human patients with myasthenia gravis, continued use of neostigmine for long-term therapy in noncrisis situations may not be accepted as being free from risk." 10/01/2011 - "Cholinergic crisis after neostigmine administration in a dog with acquired focal myasthenia gravis." 03/01/2010 - "A neuromuscular blocking drug (NMBD) induced neuromuscular blockade (NMB) in patients with myasthenia gravis usually dissipates either spontaneously or by administration of neostigmine. "
2.	Pain (Aches) 03/01/1996 - "Neostigmine was more effective for somatic pain than visceral pain. " 06/01/1995 - "However, since pain itself activates bulbospinal inhibitory pathways, neostigmine may be more effective in the postoperative period. " 12/01/2008 - "Injection of 100 microg hyperbaric neostigmine intrathecally was effective for pain relief, and reduced post-operative opiate demand." 10/01/2000 - "Efficacy of intrathecal neostigmine for the relief of postinguinal hemiorrhaphy pain." 01/01/2012 - "The neostigmine model represents a new minimally invasive mouse model to study visceral pain. "
3.	Colonic Pseudo-Obstruction (Ogilvie Syndrome) 12/01/2012 - "Colonoscopy is superior to neostigmine for Ogilvie's syndrome and should be considered first-line therapy, although neostigmine is useful in select patients and repeat interventions." 12/01/2012 - "Colonoscopy is superior to neostigmine in the treatment of Ogilvie's syndrome." 03/24/2001 - "Neostigmine was recently shown to be effective and safe for the treatment of Ogilvie's syndrome. " 05/01/2000 - "We have shown that neostigmine is a safe and effective treatment for acute colonic pseudo-obstruction." 05/01/2000 - "Neostigmine: safe and effective treatment for acute colonic pseudo-obstruction."
4.	Poisoning 11/01/1980 - "Neostigmine, however, appears to be the most effective in producing an antiblocking action of sufficient magnitude and duration of action to be of value as an antidote in NT poisoning. " 09/01/2011 - "[Neostigmine poisoning caused by mistakenly swallowing in a child]." 02/01/2008 - "We present the case of a patient who presented with a rare myasthenic crisis-like syndrome requiring assisted ventilation due to Cleistanthus collinus poisoning, which responded to treatment with neostigmine." 03/01/1991 - "[The effect of neostigmine on the motor endplate in the intermediate syndrome of organophosphate poisoning]." 11/01/1983 - "[Thiol compounds in the combined therapy of prozerin poisonings]."
5.	Paralysis (Palsy) 01/01/1957 - "[Lack of efficacy of the prostigmine test on myasthenic ocular paralysis]." 01/01/2010 - "The purpose of this study was to investigate the dose-effect relationship of neostigmine to antagonize residual paralysis corresponding to a TOF ratio of 0.4 and 0.6. " 05/01/1988 - "The effect of neostigmine on postoperative intestinal paralysis in 90 patients was investigated in a controlled study. " 08/01/2015 - "Residual paralysis is common at tracheal extubation and PACU arrival, despite qualitative neuromuscular monitoring and the use of neostigmine. " 10/01/2013 - "An experiment using aerosolized neostigmine to reverse paralysis suggests how early interventions could be developed."

Related Drugs and Biologics

1.	Glycopyrrolate (Glycopyrronium Bromide)
2.	Clonidine (ST 155)
3.	Cholinesterase Inhibitors (Anticholinesterases)
4.	Vecuronium Bromide (Vecuronium)
5.	Cisapride (Propulsid)
6.	tegaserod (Zelnorm)
7.	Metoclopramide (Reglan)
8.	Sugammadex
9.	Morphine (MS Contin)
10.	Atropine (Hyoscyamine)

Related Therapies and Procedures

1.	Analgesia
2.	Injections
3.	Intravenous Injections
4.	Aftercare (After-Treatment)
5.	Spinal Injections