Abstract | STUDY OBJECTIVE: To determine whether changes in serum glucose, serum potassium, and plasma insulin levels are correlated in a cohort of hypertensive patients. DESIGN: Prespecified subgroup analysis of results from a prospective, multicenter, randomized, open-label, parallel-group study. Setting. Primary care clinics at three tertiary care medical centers. PATIENTS: MEASUREMENTS AND MAIN RESULTS: Fasting serum glucose, serum potassium, and plasma insulin levels were obtained at baseline (before hydrochlorothiazide therapy was started) and after 9 weeks of therapy. Significant elevations were noted in fasting serum glucose (mean +/- SD 3.42 +/- 10.38 mg/dl, p<0.0001) and plasma insulin (2.35 +/- 9.47 microU/ml, p<0.0001) levels, and a significant reduction in serum potassium level (0.30 +/- 0.44 mEq/L, p<0.0001) was noted. No significant correlation was observed between changes in fasting serum glucose and potassium levels (r = 0.022, 95% confidence interval (CI) -0.120-0.164, p=0.757) or between changes in serum potassium and plasma insulin levels (r = -0.112, 95% CI -0.256-0.037, p=0.140). Changes in serum glucose levels did not differ significantly between patients maintaining serum potassium levels of 4.0 mEq/L or greater and those with levels below 4.0 mEq/L. CONCLUSION:
|
Authors | Steven M Smith, Shawn D Anderson, Sheron Wen, Yan Gong, Stephen T Turner, Rhonda M Cooper-Dehoff, Gary L Schwartz, Kent Bailey, Arlene Chapman, Karen L Hall, Hua Feng, Eric Boerwinkle, Julie A Johnson, John G Gums |
Journal | Pharmacotherapy
(Pharmacotherapy)
Vol. 29
Issue 10
Pg. 1157-65
(Oct 2009)
ISSN: 1875-9114 [Electronic] United States |
PMID | 19792989
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Chemical References |
- Antihypertensive Agents
- Blood Glucose
- Insulin
- Hydrochlorothiazide
- Potassium
|
Topics |
- Adolescent
- Adult
- Aged
- Antihypertensive Agents
(administration & dosage, adverse effects, therapeutic use)
- Blood Glucose
(drug effects)
- Female
- Humans
- Hydrochlorothiazide
(administration & dosage, adverse effects, therapeutic use)
- Hyperglycemia
(chemically induced)
- Hypertension
(drug therapy)
- Hypokalemia
(chemically induced)
- Insulin
(blood)
- Male
- Middle Aged
- Potassium
(blood)
- Randomized Controlled Trials as Topic
- Young Adult
|