COX-2 polymorphisms in patients with familial adenomatous polyposis.

Abstract

Cyclooxygenase-2 (COX-2) is an enzyme involved in the synthesis of prostaglandins and thromboxanes, which are regulators of biologic processes such as inflammation, cell proliferation, and angiogenesis. COX-2 has been found overexpressed in (pre)malignant tissues and may be relevant to cancer development. We investigated whether functional genetic polymorphisms in COX-2 may have a risk-modifying effect on duodenal adenomatosis in patients with familial adenomatous polyposis (FAP). Blood from 85 patients with FAP and 218 age- and sex-matched healthy subjects was investigated for the presence of two functional promoter region polymorphisms (-1195G-->A and -765G-->C) in COX-2. Logistic regression analysis revealed an overrepresentation of the -1195GG genotype compared to the -1195AA genotype in patients with FAP (odds ratio = 2.81; 95% CI = 1.00-7.91, p = 0.042). No associations between single COX-2 polymorphisms or COX-2 haplotype were found when patients were evaluated according to their Spigelman stage. The predicted low COX-2 expression genotype -1195GG was found overrepresented in the patients with FAP. The COX-2 genotypes showed no association with the severity of duodenal adenomatosis.

• Authors: Wilbert H M Peters, Rene H M te Morsche, Hennie M J Roelofs, Elisabeth M H Mathus-Vliegen, Marloes Berkhout, Fokko M Nagengast
• Journal: Oncology research (Oncol Res) Vol. 17 Issue 8 Pg. 347-51 ( 2009) ISSN: 0965-0407 [Print] United States
• PMID: 19544971 (Publication Type: Journal Article)

Chemical References

• Cyclooxygenase 2

Topics

• Adenomatous Polyposis Coli (enzymology, genetics, pathology)
• Adult
• Cyclooxygenase 2 (genetics)
• Female
• Genetic Predisposition to Disease
• Genotype
• Humans
• Male
• Polymerase Chain Reaction
• Polymorphism, Single Nucleotide
• Promoter Regions, Genetic (genetics)
• Risk Factors