[Evaluation of insulin resistance in type 1 diabetes with euglycemic-hyperinsulinemic clamp].

Abstract

OBJECTIVE:

To investigate insulin resistance in type 1 diabetes (T1DM) with euglycemic-hyperinsulinemic clamp.

METHODS:

Eight cases of newly diagnosed T1DM and 8 cases of newly diagnosed type 2 diabetes (T2DM) were selected. Their insulin sensitivity index (ISI) was evaluated with euglycemic-hyperinsulinemic clamp after 2 week insulin intensive treatment and compared with that of 10 healthy volunteers (normal control group, NC group).

RESULTS:

Age, BMI, fasting insulin (FIns), fasting C-peptide in the T1DM group were significantly lower than those in the NC group, while waist-to-hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), TC, TG, LDL-C, HDL-C were not significantly different between the T1DM and NC groups. Age, BMI, WHR, FIns, fasting C-peptide, SBP, TC, TG in the T1DM group were significantly lower than those in the T2DM group. The ISI of the NC, T1DM and T2DM groups were 12. 83 +/- 1.09, 9.95 +/-0.50, 3.80 +/- 0.20, respectively. There was significant difference among the three groups (P < 0.05).

CONCLUSION:

The ISI in T1DM was significantly lower than that in NC group, but higher than that in T2DM.

• Authors: Guo-chun Luo, Zhen Liang, Qing-hong Hu, De-wen Yan, Ling-bo Lü, Wen-hui Gu, Ze-long Chen, Hai-yan Li, Ming-ming Liu
• Journal: Zhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 48 Issue 1 Pg. 10-2 (Jan 2009) ISSN: 0578-1426 [Print] China
• PMID: 19484969 (Publication Type: Controlled Clinical Trial, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Insulin

Topics

• Adolescent
• Adult
• Blood Glucose (metabolism)
• Body Mass Index
• Diabetes Mellitus, Type 1 (metabolism, physiopathology)
• Diabetes Mellitus, Type 2 (metabolism)
• Female
• Glucose Clamp Technique
• Humans
• Insulin (metabolism)
• Insulin Resistance
• Male
• Middle Aged
• Waist-Hip Ratio
• Young Adult