Fatty acid composition of epicardial and subcutaneous human adipose tissue.

Abstract

BACKGROUND:

Epicardial adipose tissue has special properties that distinguish it from the more widely studied depots of adipose tissue.

OBJECTIVES:

We undertook this study to investigate regional differences between epicardial and subcutaneous adipose tissue fat composition, as well as associations between these measures and metabolic variables.

METHODS:

Epicardial and subcutaneous peripheral adipose tissue were collected during coronary artery bypass grafting from 42 patients (ages 37-65) with coronary artery disease (CAD). The fatty acid composition of adipose tissue was determined by gas liquid chromatography (GLC).

RESULTS:

The saturated fatty acids, including myristic acid (14:0), palmitic acid (16:0), and stearic acid (18:0), were higher, and the unsaturated fatty acids, including palmitoleic acid (16:1n-7), oleic acid (18:1n-9), linoleic acid (18:2n-6), and linolenic acid (18:3n-3), were lower than the subcutaneous adipose tissue. The presence of hypertension was positively correlated with the 16:1n-7 (r = 0.407, P = 0.032) and 18:1n-11(r = 0.370, P = 0.027), and negatively correlated with 18:1n-9 (r = -0.367, P = 0.036) and 18:2n-6 (r = -0.446, P = 0.006) contents of epicardial adipose tissue after adjustment for body mass index.

CONCLUSIONS:

Regional differences may be observed in fatty acid composition, suggesting a depot specific impact of stored fatty acids on adipocyte function and metabolism.

• Authors: Masoud Pezeshkian, Mohammad Noori, Hamideh Najjarpour-Jabbari, Aliakbar Abolfathi, Maryam Darabi, Masoud Darabi, Maghsod Shaaker, Ghader Shahmohammadi
• Journal: Metabolic syndrome and related disorders (Metab Syndr Relat Disord) Vol. 7 Issue 2 Pg. 125-31 (Apr 2009) ISSN: 1557-8518 [Electronic] United States
• PMID: 19422139 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Fatty Acids
• Fatty Acids, Unsaturated

Topics

• Adipose Tissue, White (chemistry)
• Adult
• Aged
• Coronary Artery Bypass
• Coronary Artery Disease (metabolism, surgery)
• Fatty Acids (analysis)
• Fatty Acids, Unsaturated (analysis)
• Female
• Humans
• Hypertension (metabolism)
• Male
• Middle Aged
• Pericardium (chemistry)
• Subcutaneous Fat (chemistry)