Circulating angiotensin II is associated with body fat accumulation and insulin resistance in obese subjects with type 2 diabetes mellitus.

Abstract

Adipocytes express all components of the renin-angiotensin system, and the renin-angiotensin system is involved in obesity and insulin resistance. Circulating angiotensin II (Ang II) is detectable in blood, but its significance in human obesity remains unknown. The aim of this study was to investigate plasma Ang II in obese patients with type 2 diabetes mellitus (T2D) and the change during weight loss. Fifty Japanese obese subjects with T2D (body weight, 75.0 +/- 14.1 kg; body mass index, 29.1 +/- 3.7 kg/m(2); visceral fat area [VFA], 169.3 +/- 54.3 cm(2); hemoglobin A(1c), 7.6% +/- 1.5%) were enrolled. The subjects were prescribed a diet of daily caloric intake of 20 kcal/kg for 24 weeks. Plasma Ang II was measured by radioimmunoassay. Leptin, adiponectin, and lipoprotein lipase mass in preheparin serum were also measured as adipocyte-derived factors. After 24 weeks of weight reduction diet, the mean body weight, VFA, and hemoglobin A(1c) decreased significantly by 2.3%, 7.0%, and 8.3%, respectively. The mean plasma Ang II decreased by 24% (P < .0001) and correlated with body weight both at baseline (r = 0.425, P = .0018) and at 24 weeks (r = 0.332, P = .0181). The change in Ang II correlated with changes in body weight (r = 0.335, P = .0167) and VFA (r = 0.329, P = .0191). The change in Ang II also correlated positively with change in leptin (r = 0.348, P = .0127) and tended to correlate negatively with change in lipoprotein lipase mass in preheparin serum (r = -0.260, P = .0683), which is a marker of insulin sensitivity. Plasma Ang II is associated with body weight, decreases during weight loss, and is associated with markers of insulin resistance in obese subjects with T2D.

• Authors: Atsuhito Saiki, Masahiro Ohira, Kei Endo, Nobukiyo Koide, Tomokazu Oyama, Takeyoshi Murano, Hitoshi Watanabe, Yoh Miyashita, Kohji Shirai
• Journal: Metabolism: clinical and experimental (Metabolism) Vol. 58 Issue 5 Pg. 708-13 (May 2009) ISSN: 1532-8600 [Electronic] United States
• PMID: 19375596 (Publication Type: Journal Article)

Chemical References

• ADIPOQ protein, human
• Adiponectin
• Glycated Hemoglobin A
• Leptin
• Angiotensin II
• Lipoprotein Lipase

Topics

• Adiponectin (blood)
• Adipose Tissue (pathology)
• Angiotensin II (blood)
• Blood Pressure (physiology)
• Diabetes Mellitus, Type 2 (blood, pathology)
• Female
• Glycated Hemoglobin (metabolism)
• Humans
• Insulin Resistance (physiology)
• Leptin (blood)
• Lipoprotein Lipase (blood)
• Male
• Middle Aged
• Obesity (blood, pathology)
• Tomography, X-Ray Computed
• Weight Loss (physiology)