Serum resistin concentrations and risk of new onset heart failure in older persons: the health, aging, and body composition (Health ABC) study.

Abstract

OBJECTIVE:

Resistin is associated with inflammation and insulin resistance and exerts direct effects on myocardial cells including hypertrophy and altered contraction. We investigated the association of serum resistin concentrations with risk for incident heart failure (HF) in humans.

METHODS AND RESULTS:

We studied 2902 older persons without prevalent HF (age, 73.6+/-2.9 years; 48.1% men; 58.8% white) enrolled in the Health, Aging, and Body Composition (Health ABC) Study. Correlation between baseline serum resistin concentrations (20.3+/-10.0 ng/mL) and clinical variables, biochemistry panel, markers of inflammation and insulin resistance, adipocytokines, and measures of adiposity was weak (all rho <0.25). During a median follow-up of 9.4 years, 341 participants (11.8%) developed HF. Resistin was strongly associated with risk for incident HF in Cox proportional hazards models controlling for clinical variables, biomarkers, and measures of adiposity (HR, 1.15 per 10.0 ng/mL in adjusted model; 95% CI, 1.05 to 1.27; P=0.003). Results were comparable across sex, race, diabetes mellitus, and prevalent and incident coronary heart disease subgroups. In participants with available left ventricular ejection fraction at HF diagnosis (265 of 341; 77.7%), association of resistin with HF risk was comparable for cases with reduced versus preserved ejection fraction.

CONCLUSIONS:

Serum resistin concentrations are independently associated with risk for incident HF in older persons.

• Authors: Javed Butler, Andreas Kalogeropoulos, Vasiliki Georgiopoulou, Nathalie de Rekeneire, Nicolas Rodondi, Andrew L Smith, Udo Hoffmann, Alka Kanaya, Anne B Newman, Stephen B Kritchevsky, Ramachandran S Vasan, Peter W F Wilson, Tamara B Harris, Health ABC Study
• Journal: Arteriosclerosis, thrombosis, and vascular biology (Arterioscler Thromb Vasc Biol) Vol. 29 Issue 7 Pg. 1144-9 (Jul 2009) ISSN: 1524-4636 [Electronic] United States
• PMID: 19372460 (Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural)

Chemical References

• Biomarkers
• Resistin

Topics

• Black or African American
• Aged
• Biomarkers (blood)
• Female
• Follow-Up Studies
• Heart Failure (blood)
• Humans
• Male
• Proportional Hazards Models
• Resistin (blood)
• Risk
• Ventricular Dysfunction, Left (blood)
• Ventricular Function, Left
• White People