Ciclesonide therapy in asthma: a potential effect on small airway inflammation?

Abstract

BACKGROUND:

In asthma small airways inflammation often persists despite inhaled corticosteroids therapy.

OBJECTIVE:

To discuss the effects of ciclesonide, a newer inhaled corticosteroid on small airways inflammation and the reliability of some biomarkers of small airways inflammation in asthma.

METHODS AND RESULTS:

Evaluation of a study assessing the short-term effects of ciclesonide on small airways inflammation in patients with mild to moderate asthma.

CONCLUSIONS:

Ciclesonide could have beneficial effects on small airways inflammation and some of the outcome measures used as efficacy endpoints could represent possible biomarkers of small airways involvement in obstructive chronic respiratory diseases.

• Authors: Sabina Antonela Antoniu, Carmen Monica Pop
• Journal: Expert opinion on pharmacotherapy (Expert Opin Pharmacother) Vol. 10 Issue 5 Pg. 917-9 (Apr 2009) ISSN: 1744-7666 [Electronic] England
• PMID: 19351238 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Asthmatic Agents
• Inflammation Mediators
• Pregnenediones
• ciclesonide

Topics

• Administration, Inhalation
• Anti-Asthmatic Agents (therapeutic use)
• Asthma (drug therapy, physiopathology)
• Bronchial Hyperreactivity (drug therapy, physiopathology)
• Humans
• Inflammation Mediators (therapeutic use)
• Pilot Projects
• Pregnenediones (therapeutic use)
• Pulmonary Alveoli (drug effects, pathology)