Abstract | OBJECTIVE: MATERIALS AND METHODS: RESULTS: AUR increased the intravesical pressure and decreased blood flow, and subsequent catheterization decreased the intravesical pressure and increased blood flow. Edaravone induced a decrease in blood flow in the bladder during the urinary retention and subsequent catheterization compared to the blood flow in the AUR group. Edaravone resulted in protection of the contractile responses to both carbachol and KCl in a dose-dependent manner. The MDA concentration, 8-OHdG content and expressions of HSP-70 and its mRNA in the AUR group were significantly larger than those of the control group. Edaravone markedly suppressed the accumulations of MDA and 8-OHdG in the bladder, and reduced the expressions of HSP 70 and its mRNA. CONCLUSION: These results indicate that edaravone reduces the oxidative stress and prevents the bladder dysfunction caused by AUR and subsequent catheterization.
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Authors | Shogo Shimizu, Motoaki Saito, Yukako Kinoshita, Emi Kazuyama, Mayuko Tamamura, Itaru Satoh, Keisuke Satoh |
Journal | BJU international
(BJU Int)
Vol. 104
Issue 5
Pg. 713-7
(Sep 2009)
ISSN: 1464-410X [Electronic] England |
PMID | 19338546
(Publication Type: Journal Article)
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Chemical References |
- Free Radical Scavengers
- HSP70 Heat-Shock Proteins
- Malondialdehyde
- 8-Hydroxy-2'-Deoxyguanosine
- Deoxyguanosine
- Edaravone
- Antipyrine
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Topics |
- 8-Hydroxy-2'-Deoxyguanosine
- Acute Disease
- Animals
- Antipyrine
(analogs & derivatives, pharmacology)
- DNA Damage
(drug effects)
- Deoxyguanosine
(analogs & derivatives, metabolism)
- Edaravone
- Free Radical Scavengers
(pharmacology)
- HSP70 Heat-Shock Proteins
(metabolism)
- Lipid Peroxidation
(drug effects)
- Male
- Malondialdehyde
(metabolism)
- Oxidative Stress
(drug effects)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Urinary Bladder Diseases
(metabolism, prevention & control)
- Urinary Catheterization
- Urinary Retention
(prevention & control)
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