Abstract | AIM: MATERIAL AND METHODS:
DNA was obtained from peripheral blood of 90 CP patients and 126 periodontally healthy subjects, and the clinical parameters were recorded. ACE I/D, AGT M235T and AT1R A1166C polymorphisms were genotyped by the PCR-RFLP method. Chi-square, anova and logistic regression methods were used in statistical analyses. RESULTS: The frequency of the ACE D allele was significantly lower in the CP group than the healthy group (p(corr)=0.015). CP subjects exhibited increased C allele carriage and C allele frequency of the AT1R gene (p(corr)=0.03 and p(corr)=0.03, respectively). All clinical parameters of CP patients were found to be similar in variant allele-carrying and non-carrying subjects (p>0.05). CONCLUSIONS: The present findings suggest that ACE I/D and AT1R polymorphisms might be associated with susceptibility to CP but not with disease severity. The D allele of ACE I/D might be associated with decreased, whereas the C variant of AT1R A1166C might be associated with an elevated risk for CP in Turkish population.
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Authors | Ali Gürkan, Gülnur Emingil, Buket Han Saygan, Gül Atilla, Timur Köse, Haluk Baylas, Afig Berdeli |
Journal | Journal of clinical periodontology
(J Clin Periodontol)
Vol. 36
Issue 3
Pg. 204-11
(Mar 2009)
ISSN: 1600-051X [Electronic] United States |
PMID | 19236533
(Publication Type: Journal Article)
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Chemical References |
- Receptor, Angiotensin, Type 1
- Angiotensinogen
- Peptidyl-Dipeptidase A
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Topics |
- Adult
- Analysis of Variance
- Angiotensinogen
(genetics)
- Case-Control Studies
- Chi-Square Distribution
- Chronic Periodontitis
(genetics)
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Peptidyl-Dipeptidase A
(genetics)
- Receptor, Angiotensin, Type 1
(genetics)
- Reference Values
- Renin-Angiotensin System
(genetics)
- Severity of Illness Index
- Turkey
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