Effect of Tectona grandis Linn. on dexamethasone-induced insulin resistance in mice.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

The bark of Tectona grandis Linn. is traditionally used in the treatment of diabetes.

AIM:

The present study was undertaken to investigate the effect of ethanolic extract of bark of Tectona grandis Linn. (TG) in dexamethasone-induced insulin resistance in mice.

MATERIALS AND METHODS:

Mice were treated with prestandardised dose of dexamethasone for 22 days and effect of TG at the doses of 50, 100 and 200 mg/kg, p.o. on plasma blood glucose level, serum triglyceride level, glucose uptake in skeletal muscle, levels of hepatic antioxidant enzymes (GSH, SOD, catalase and LPO), and body weight were observed.

RESULTS:

TG showed significant decrease in plasma glucose and serum triglyceride levels (p<0.01) at the dose of 100 and 200 mg/kg, p.o. and also stimulated glucose uptake in skeletal muscle. The levels of antioxidant enzymes GSH, SOD, and catalase were significantly increased (p<0.01) and there was significant decrease (p<0.01) in level of LPO.

CONCLUSION:

Hence it can be concluded that Tectona grandis may prove to be effective in the treatment of Type-II Diabetes mellitus owing to its ability to decrease insulin resistance.

• Authors: Mahesh Ghaisas, Vijay Navghare, Abhijit Takawale, Vinit Zope, Mukesh Tanwar, Avinash Deshpande
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 122 Issue 2 Pg. 304-7 (Mar 18 2009) ISSN: 1872-7573 [Electronic] Ireland
• PMID: 19168121 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Blood Glucose
• Hypoglycemic Agents
• Plant Extracts
• Thiazolidinediones
• Triglycerides
• Dexamethasone
• Pioglitazone

Topics

• Animals
• Antioxidants (metabolism, pharmacology, therapeutic use)
• Blood Glucose
• Body Weight (drug effects)
• Dexamethasone
• Diabetes Mellitus, Type 2 (prevention & control)
• Diaphragm (drug effects)
• Dose-Response Relationship, Drug
• Hypoglycemic Agents (pharmacology, therapeutic use)
• Insulin Resistance
• Liver (enzymology)
• Mice
• Phytotherapy
• Pioglitazone
• Plant Bark
• Plant Extracts (pharmacology, therapeutic use)
• Thiazolidinediones (pharmacology, therapeutic use)
• Triglycerides (blood)
• Verbenaceae