Abstract | BACKGROUND: OBJECTIVE: To examine whether calprotectin might be an independent predictor of joint destruction over time. METHODS: RESULTS: At both examinations the highest calprotectin levels were found in patients positive for anti-CCP, IgA and IgM RF. Calprotectin had moderate to good correlations with inflammatory and serological markers (r = 0.41-0.67). Patients with normal baseline calprotectin levels had a lower degree of joint damage. High univariate associations were found between baseline calprotectin levels and progression in the Sharp score as well as the RAAD score. Baseline calprotectin was independently associated with progression in the Sharp score and with the RAAD score in multiple linear regression analyses, including baseline levels of CRP, ESR, anti-CCP in addition to demographic variables. CONCLUSION:
Calprotectin was an independent predictor of clinical and radiographic joint damage after 10 years. These findings support the proposal that calprotectin may be a prognostic biomarker for erosive disease in patients with RA.
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Authors | H Berner Hammer, S Ødegård, S W Syversen, R Landewé, D van der Heijde, T Uhlig, P Mowinckel, T K Kvien |
Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 69
Issue 1
Pg. 150-4
(Jan 2010)
ISSN: 1468-2060 [Electronic] England |
PMID | 19095696
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Inflammation Mediators
- Leukocyte L1 Antigen Complex
- Rheumatoid Factor
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Topics |
- Adult
- Arthritis, Rheumatoid
(blood, diagnosis, diagnostic imaging)
- Biomarkers
(blood)
- Disease Progression
- Female
- Follow-Up Studies
- Humans
- Inflammation Mediators
(blood)
- Leukocyte L1 Antigen Complex
(blood)
- Male
- Middle Aged
- Prognosis
- Radiography
- Rheumatoid Factor
(blood)
- Severity of Illness Index
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