[Case of interstitial pneumonia induced by intravesical administration of Bacillus Calmette-Guerin].

Abstract

An 81-year-old man with superficial bladder cancer, which was detected after he complained of hematuria and pain on urination, was treated 5 times with intravesical bacillus Calmette-Guerin (BCG) administration. Since he complained of a dry cough and dyspnea associated with severe hypoxemia, and had extensive bilateral pulmonary infiltrative shadows on his chest X-ray film, he was admitted to our hospital. He was treated with methylprednisolone under a diagnosis of interstitial pneumonia. Because BCG infection and/or bacterial pneumonia could not be denied, we administered antituberculosis agent and antibiotics. However, he died due to respiratory failure on 10th day after admission. Because a lymphocyte stimulation test for BCG was strongly positive, we established a diagnosis of interstitial pneumonia induced by intravesical administration of BCG. Because the mortality rate is high, the evaluation of interstitial pneumonia before administration of BCG is crucial.

• Authors: Akihito Yamamoto, Ryo Koyama, Kenji Kido, Kengo Koike, Michie Toba, Kazuhisa Takahashi
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 46 Issue 10 Pg. 803-7 (Oct 2008) ISSN: 1343-3490 [Print] Japan
• PMID: 19044030 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• BCG Vaccine

Topics

• Administration, Intravesical
• Aged, 80 and over
• BCG Vaccine (administration & dosage, adverse effects)
• Fatal Outcome
• Humans
• Lung Diseases, Interstitial (etiology)
• Male
• Respiratory Insufficiency (etiology)
• Urinary Bladder Neoplasms (therapy)