Abstract | BACKGROUND: METHODS:
Tumor tissue microarray was used to detect the expression levels of OPN and CD44 in 302 hepatocellular carcinoma patients undergoing curative resection between 1997 and 2000 at our institute. Clinicopathologic data for these patients were investigated. The prognostic effects of OPN and CD44 were evaluated using the Kaplan-Meier method and compared using the log-rank test. The Spearman rank test and Fisher's exact test were applied to demonstrate correlations. RESULTS: Both OPN and CD44 were independent predictors for overall survival and disease-free survival. When OPN and CD44 were taken into consideration together, the predictive range was extended and the sensitivity was improved, especially for those patients with normal serum alpha-fetoprotein levels. The 8-year overall survival and disease-free survival rates in OPN+ and/or CD44+ patients were 28.2% and 25.6%, respectively, which were significantly lower than those of OPN-CD44- patients (52.1% and 51.6%, respectively). CONCLUSIONS:
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Authors | Guo-Huan Yang, Jia Fan, Yang Xu, Shuang-Jian Qiu, Xin-Rong Yang, Guo-Ming Shi, Bing Wu, Zhi Dai, Yin-Kun Liu, Zhao-You Tang, Jian Zhou |
Journal | The oncologist
(Oncologist)
Vol. 13
Issue 11
Pg. 1155-65
(Nov 2008)
ISSN: 1549-490X [Electronic] England |
PMID | 18997126
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Hyaluronan Receptors
- alpha-Fetoproteins
- Osteopontin
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Topics |
- Adult
- Aged
- Biomarkers, Tumor
(analysis)
- Carcinoma, Hepatocellular
(chemistry, mortality, pathology, surgery)
- Female
- Humans
- Hyaluronan Receptors
(analysis)
- Liver Neoplasms
(chemistry, mortality, pathology, surgery)
- Male
- Middle Aged
- Osteopontin
(analysis)
- Prognosis
- Sensitivity and Specificity
- Tissue Array Analysis
- alpha-Fetoproteins
(analysis)
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