G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan.

Abstract

Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Han Chinese SLE patients and a healthy control group in Taiwan. Our results indicate (a) a significantly higher G allele frequency in SLE patients (P=1.91 x 10(-14); OR=3.94; 95% CI=2.74-5.66), (b) a significantly higher G allele frequency in SLE patients with antinuclear antibodies (ANA) (P=0.033; OR=4.21; 95% CI=1.01-17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P=0.019; OR=0.41; 95% CI=0.19-0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE.

• Authors: Ying-Ju Lin, Lei Wan, Jim Jinn-Chyuan Sheu, Chung-Ming Huang, Cheng-Wen Lin, Yu-Ching Lan, Chih-Ho Lai, Chien-Hui Hung, Yuhsin Tsai, Chang-Hai Tsai, Wei-Yong Lin, Hsin-Ping Liu, Ting-Hsu Lin, Yu-Min Huang, Fuu-Jen Tsai
• Journal: Clinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 129 Issue 1 Pg. 36-9 (Oct 2008) ISSN: 1521-7035 [Electronic] United States
• PMID: 18650128 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-2

Topics

• Alleles
• Exons
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• Interleukin-2 (genetics)
• Lupus Erythematosus, Systemic (genetics, immunology)
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Polymorphism, Restriction Fragment Length
• Taiwan