Abstract | BACKGROUND: METHODS: Plasma glucose, insulin, c-peptide and insulin resistance (homeostasis model assessment, HOMA) were determined in 44 HIV patients [16 without HAART, 19 with protease inhibitors (PI), 9 without PI (non-PI)] and in 11 healthy subjects. Glucose tolerance was determined by standard procedures. Body mass index (BMI), triceps skin fold thickness and waist circumference were measured and the waist-to-hip-ratio was calculated. Familial disposition for DM was assessed by questionnaire. RESULTS: Impaired fasting glucose was observed in 28% of HAART-treated patients (21% with PI, 7% non-PI), in 13% of HAART-naive but none in healthy controls. 58% of PI, 44% of non-PI, 38% of HAART-naive and none of healthy controls had a HOMA-index > 2.5 which indicates insulin resistance. HAART-treated patients had significantly higher fasting glucose levels (PI: 97 +/- 11 mg/dL, p = 0.048; non-PI: 109 +/- 58 mg/dL, p = 0.009) compared to healthy controls (72 +/- 8 mg/dL). HOMA-Index was higher in PI treated patients (3.74 +/- 3.08) than in HIV negative controls (0.95 +/- 0.28, p = 0.018). The duration of HAART (p = 0.045), overweight and familial disposition for DM (p = 0.017) significantly affected fasting glucose among PI users. Waist circumference affected c-peptide (p = 0.046) concentration in these patients. CONCLUSION: HIV patients on long-term PI therapy with overweight and familial disposition for DM are at high risk to develop abnormalities of glucose metabolism. Thus, measurements of HOMA-Index, BMI and waist circumference should be routinely done especially in PI medicated patients.
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Authors | S C Blass, S Ellinger, M Vogel, P Ingiliz, U Spengler, P Stehle, A von Ruecker, Juergen K Rockstroh |
Journal | European journal of medical research
(Eur J Med Res)
Vol. 13
Issue 5
Pg. 209-14
(May 26 2008)
ISSN: 0949-2321 [Print] England |
PMID | 18559303
(Publication Type: Journal Article)
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Chemical References |
- HIV Protease Inhibitors
- Glucose
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Topics |
- Abdominal Fat
(metabolism)
- Adult
- Aged
- Antiretroviral Therapy, Highly Active
- Female
- Glucose
(metabolism)
- HIV Infections
(drug therapy, metabolism)
- HIV Protease Inhibitors
(therapeutic use)
- Humans
- Male
- Middle Aged
- Overweight
(metabolism)
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