Abstract | OBJECTIVE: METHODS: RESULTS: The cytotoxicity of the spleen cells or purified CD8(+) T cells against Lewis cells in the mice immunized with cancer cell vaccine was significantly increased, relative to that of the control, untreated group (P < 0.05). Serum level of Th1-type cytokine IFN-gamma was increased after vaccination, whereas Th2-type cytokine IL-4 showed no significant change. The GM-CSF secreting cancer cell vaccine had no significant influence on the survival of the mice with established heavy tumor burden. The combination of chemotherapy and cancer vaccine could statistically prolong the survival time; whereas any method itself had no significant effect. CONCLUSION:
|
Authors | Hong-Jing Jiang, Xiu-Bao Ren, Hui Li, Jin-Pu Yu, Feng Wei, Ming-Quan Ma |
Journal | Zhonghua zhong liu za zhi [Chinese journal of oncology]
(Zhonghua Zhong Liu Za Zhi)
Vol. 29
Issue 11
Pg. 808-12
(Nov 2007)
ISSN: 0253-3766 [Print] China |
PMID | 18396635
(Publication Type: English Abstract, Journal Article)
|
Chemical References |
- Antineoplastic Agents
- Cancer Vaccines
- Interleukin-4
- Interferon-gamma
- Granulocyte-Macrophage Colony-Stimulating Factor
- Carboplatin
|
Topics |
- Animals
- Antineoplastic Agents
(therapeutic use)
- Cancer Vaccines
(therapeutic use)
- Carboplatin
(therapeutic use)
- Carcinoma, Lewis Lung
(blood, metabolism, pathology, therapy)
- Cell Line, Tumor
- Female
- Granulocyte-Macrophage Colony-Stimulating Factor
(genetics, metabolism)
- Interferon-gamma
(blood)
- Interleukin-4
(blood)
- Lung Neoplasms
(metabolism, pathology)
- Mice
- Mice, Inbred C57BL
- Transfection
|