Abstract | AIM OF THE STUDY: The analgesic and anti-inflammatory activities of the ethanol extract of Aquilaria sinensis (Lour.) Gilg. Leaves were observed in various experimental models related to nociception and inflammation, so as to provide some evidence for its traditional use. MATERIALS AND METHODS: RESULTS: The ethanol extract significantly inhibited acetic acid-induced writhing after single oral administration at doses of 424 and 848 mg extract/kg, and the response to the thermal stimulus in mice at the dose of 848 mg/kg. Meanwhile, the ethanol extract also remarkably lessened xylene-induced ear swelling, carrageenan-induced paw edema, and CMC-Na-induced leukocyte migration. Furthermore, the extract considerably reduced NO release from LPS-stimulated macrophages with IC50 of 80.4 mg/ml. CONCLUSION: These findings suggest that Aquilaria sinensis (Lour.) Gilg. Leaves extract present notable analgesic and anti-inflammatory activities, which support its folkloric use for some diseases related with painful and inflammatory conditions such as trauma etc.
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Authors | Minhua Zhou, Honggang Wang, Suolangjiba, Junping Kou, Boyang Yu |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 117
Issue 2
Pg. 345-50
(May 08 2008)
ISSN: 0378-8741 [Print] Ireland |
PMID | 18353573
(Publication Type: Journal Article)
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Chemical References |
- Analgesics
- Anti-Inflammatory Agents, Non-Steroidal
- Indicators and Reagents
- Lipopolysaccharides
- Plant Extracts
- Xylenes
- Nitric Oxide
- Carrageenan
- Acetic Acid
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Topics |
- Acetic Acid
- Analgesics
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
- Carrageenan
- Cell Migration Assays, Leukocyte
- Cell Survival
(drug effects)
- Edema
(chemically induced, prevention & control)
- Female
- Hot Temperature
- Indicators and Reagents
- Lipopolysaccharides
(pharmacology)
- Macrophages
(drug effects)
- Male
- Mice
- Mice, Inbred ICR
- Nitric Oxide
(metabolism)
- Pain Measurement
(drug effects)
- Plant Extracts
(pharmacology)
- Plant Leaves
(chemistry)
- Reaction Time
(drug effects)
- Thymelaeaceae
(chemistry)
- Xylenes
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