Cerebrospinal fluid cytokine responses in human eosinophilic meningitis associated with angiostrongyliasis.

Abstract

The levels of interleukin 5 (IL5), IL10, and IL13 in the cerebrospinal fluid (CSF) were markedly higher in 30 patients with eosinophilic meningitis associated with angiostrongyliasis (EOMA) than in the controls (P<0.001). IL2, IL4, interferon gamma (IFNgamma), and tumor necrosis factor alpha (TNFalpha) levels were not significantly different (P>0.05). IL5, IL10, and TNFalpha levels correlated with eosinophil levels (P=0.023, P=0.018, and P=0.005, respectively) while IL2, IL4, IL13, and IFNgamma did not (P>0.05). Our data suggest that local T-helper-2 (TH2) cytokine responses are predominant in the CSF of patients with EOMA. Data on T lymphocyte-parasite interactions are important for the design of effective vaccines and immunotherapies. The measurement of T-helper-1 (TH1)/TH2 cytokines in the CSF may also have some potential for the diagnosis of parasite associated meningitis.

• Authors: Pewpan M Intapan, Suvicha Kittimongkolma, Kanigar Niwattayakul, Kittisak Sawanyawisuth, Wanchai Maleewong
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 267 Issue 1-2 Pg. 17-21 (Apr 15 2008) ISSN: 0022-510X [Print] Netherlands
• PMID: 17928005 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Cytokines
• Interleukin-13
• Interleukin-5
• Interleukin-10

Topics

• Adolescent
• Adult
• Angiostrongylus cantonensis (immunology)
• Animals
• Biomarkers (analysis, cerebrospinal fluid)
• Child
• Cytokines (cerebrospinal fluid, metabolism)
• Eosinophilia (cerebrospinal fluid, immunology, parasitology)
• Eosinophils (immunology, metabolism)
• Female
• Host-Parasite Interactions (immunology)
• Humans
• Immunity, Cellular (immunology)
• Interleukin-10 (cerebrospinal fluid, metabolism)
• Interleukin-13 (cerebrospinal fluid, metabolism)
• Interleukin-5 (cerebrospinal fluid, metabolism)
• Male
• Meningitis (cerebrospinal fluid, immunology, parasitology)
• Middle Aged
• Strongylida Infections (cerebrospinal fluid, complications, immunology)
• Th2 Cells (immunology)