Abstract | INTRODUCTION: Increased (18)F-fluorodeoxyglucose (FDG) uptake in inflammatory lesions, particularly in granulomatous inflammation (e.g., sarcoidosis), makes it difficult to differentiate malignant tumors from benign lesions and is the main source of false-positive FDG-PET findings in oncology. Here, we developed a rat granuloma model and examined FDG uptake in the granuloma. The effects of corticosteroid on FDG uptake in the granuloma were compared with those in a malignant tumor. METHODS: Rats were inoculated with Mycobacterium bovis bacillus Calmette-Guérin (BCG) or allogenic hepatoma cells, and subdivided into control and pretreated ( methylprednisolone acetate, 8 mg/kg i.m.) groups. Radioactivity in tissues was determined 1 h after the FDG injection. FDG-PET was performed in rats bearing BCG granulomas or tumors before and after prednisolone treatment. RESULTS: CONCLUSION: We developed an intramuscular granuloma rat model that showed a high FDG uptake comparable to that of the tumor. The effect of prednisolone pretreatment on FDG uptake was greater in the granuloma than in the tumor. These results suggest that BCG-induced granuloma may be a valuable model and may provide a biological basis for FDG studies.
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Authors | Songji Zhao, Yuji Kuge, Masashi Kohanawa, Toshiyuki Takahashi, Hidekazu Kawashima, Takashi Temma, Toshiki Takei, Yan Zhao, Koh-ichi Seki, Nagara Tamaki |
Journal | European journal of nuclear medicine and molecular imaging
(Eur J Nucl Med Mol Imaging)
Vol. 34
Issue 12
Pg. 2096-105
(Dec 2007)
ISSN: 1619-7070 [Print] Germany |
PMID | 17763849
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glucocorticoids
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
- Prednisolone
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Topics |
- Animals
- Carcinoma, Hepatocellular
(diagnostic imaging, metabolism)
- Cell Line, Tumor
- Diagnosis, Differential
- Disease Models, Animal
- Fluorodeoxyglucose F18
(pharmacokinetics)
- Glucocorticoids
(administration & dosage)
- Granuloma
- Liver Neoplasms
(diagnostic imaging, metabolism)
- Male
- Metabolic Clearance Rate
- Prednisolone
(administration & dosage)
- Radionuclide Imaging
- Radiopharmaceuticals
- Rats
- Rats, Wistar
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